N-methylnicotinamide hydrochloride | 29711-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-methylnicotinamide hydrochloride
• 英文别名: N'-methylnicotinamide chloride；Methyl(pyridine-3-carbonyl)azanium;chloride
• CAS: 29711-57-7
• 化学式: C₇H₈N₂O*ClH
• 分子量: 172.614
• InChiKey: IDGQLRKIJLKDRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.86
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-甲氧基苯基)乙胺盐酸盐 、 N-methylnicotinamide hydrochloride 生成
  参考文献：
  名称：

  On the interactions of catecholamines with N-methylnicotinamide cation: a UV spectral study

  摘要：

  DOI：

  10.1016/0223-5234(89)90014-7
• 作为产物：
  描述：

  生成 2-(4-甲氧基苯基)乙胺盐酸盐 、 N-methylnicotinamide hydrochloride
  参考文献：
  名称：

  On the interactions of catecholamines with N-methylnicotinamide cation: a UV spectral study

  摘要：

  DOI：

  10.1016/0223-5234(89)90014-7

文献信息

• [EN] SOLUTIONS FOR PROTECTING, PERFUSING AND STORING ORGANS DURING SURGICAL PROCEDURES IN PARTICULAR TRANSPLANTATIONS<br/>[FR] SOLUTIONS POUR PROTÉGER, PERFUSER ET STOCKER DES ORGANES PENDANT DES INTERVENTIONS CHIRURGICALES, EN PARTICULIER PENDANT DES TRANSPLANTATIONS
  申请人：TRANSMEDIUM SP Z O O

  公开号：WO2014042545A1

  公开（公告）日：2014-03-20

  A solution for protecting, storing and perfusing organs during transplantation and other surgical procedures containing osmolytes and oncolytes, electrolytes, substances with antioxidant activity, cryoprotectants, cytoskeleton stabilizers, precursors for the synthesis of high-energy adenylates, apoptosis inhibitors, and a stimulator of endothelial cell regeneration. A solution according to the present invention contains: trehalose at a concentration from 1 m M to 50 m M, inosine at a concentration from 0.1 mM to 5 mM, α-ketobutyric acid or its salts at a concentration from 0.1 mM to 25 m M, aurintricarboxylic acid or its salts at concentrations from 0.01 m M to 1 m M and N-methylnicotinamide at a concentration from 0.1 mM to 5 m M. The scope of uses of said solution encompasses perfusion and storage at low temperature of organs collected from a donor or one subjected to a surgical procedure.

  一种用于保护、储存和灌注器官在移植和其他外科手术过程中的溶质和渗透剂、电解质、具有抗氧化活性的物质、抗冻剂、细胞骨架稳定剂、高能腺苷酸合成前体、凋亡抑制剂和内皮细胞再生刺激剂的溶液。根据本发明的一种溶液包含：浓度为1mM至50mM的海藻糖，浓度为0.1mM至5mM的肌酸，α-酮丁酸或其盐的浓度为0.1mM至25mM，柠檬酸金三羧酸或其盐的浓度为0.01mM至1mM，以及N-甲基烟酰胺的浓度为0.1mM至5mM。所述溶液的用途范围包括对从供体或接受外科手术的个体收集的器官进行低温灌注和储存。
• Methods of detecting poly(adp-ribose) polymerase and other nad+ utilizing enzymes
  申请人：Hergenrother J. Paul

  公开号：US20070078100A1

  公开（公告）日：2007-04-05

  Methods for detecting poly (ADP-ribose) polymerase and other NAD+ utilizing enzymes.

  检测聚(ADP-核糖)聚合酶和其他利用NAD+的酶的方法。
• Method of treating endothelial dysfunction
  申请人：Celagenex Research (India) Pvt. Ltd.

  公开号：US10864207B2

  公开（公告）日：2020-12-15

  The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N1-methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N1-methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1:0.5 to 1:8; and N1-methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1:0.1 to 1:1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.

  本发明公开了用于改善血管内皮功能的血管活性介质增强剂的强效协同组合物。特别是，本发明涉及由氯化 N1-甲基烟酰胺和富含硝酸盐的标准化红菠菜提取物以及药学上可接受的赋形剂组成的外源混合协同营养组合物，其中氯化 N1-甲基烟酰胺盐和富含硝酸盐的标准化红菠菜提取物的比例为 1:0.5 至 1:8；氯化 N1-甲基烟酰胺和标准化红菠菜提取物的硝酸盐的比例为 1:0.1 至 1:1。本增效组合物可用于治疗高血压、动脉粥样硬化、血栓形成、心肌梗塞、心脏损伤等内皮功能障碍。
• USE OF VITAMIN PP COMPOUNDS
  申请人：Klinge Pharma GmbH

  公开号：EP1079832A1

  公开（公告）日：2001-03-07
• SOLUTIONS FOR PROTECTING, PERFUSING AND STORING ORGANS DURING SURGICAL PROCEDURES IN PARTICULAR TRANSPLANTATIONS
  申请人：Transmedium Sp. z o.o.

  公开号：EP2894975A1

  公开（公告）日：2015-07-22