3-ethylnaphthalen-1-ol | 147730-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-ethylnaphthalen-1-ol
• 英文别名: 3-ethyl-1-naphthol；3-ethyl-[1]naphthol；4-Hydroxy-2-aethyl-naphthalin；3-Aethyl-[1]naphthol
• CAS: 147730-07-2
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: TXXQNKDYOXGLQS-UHFFFAOYSA-N

物化性质

• 熔点：
  50-51 °C
• 沸点：
  170 °C(Press: 14 Torr)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-ethylnaphthalen-1-ol 在 tris-(dibenzylideneacetone)dipalladium(0) 18-冠醚-6 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 4-(3-ethyl-naphthalen-1-yl)-piperazine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands

  摘要：

  4-Sulfonyl analogs of 1-(1-naphthyl)piperazine bind at human 5-HT6 receptors and represent a novel class of human 5-HT6 receptor ligands. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.031
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 selenium 作用下， 生成 3-ethylnaphthalen-1-ol
  参考文献：
  名称：

  Levy, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1932, vol. 194, p. 1952

  摘要：

  DOI：

文献信息

• Concise Synthesis of 1-Naphthols under Mild Conditions through a Copper-Catalyzed Arylation of Methyl Ketones
  作者：Zhenbang Lou、Shu Zhang、Chao Chen、Xinlong Pang、Ming Li、Lirong Wen

  DOI：10.1002/adsc.201300728

  日期：2014.1.13

  A concise synthesis of 1‐naphthols via cyclization of o‐iodoacetophenones and methyl ketones has been realized under very mild conditions. The cyclization process is initiated by a rare copper‐catalyzed arylation of simple methyl ketones with ortho‐iodoacetophenones.

  在非常温和的条件下，已经可以通过邻碘苯乙酮和甲基酮的环合反应合成1-萘酚。环化过程是由稀有铜催化的简单甲基酮与邻碘苯乙酮的芳基化而引发的。
• Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones
  作者：Zhen-Bang Lou、Xin-Long Pang、Chao Chen、Li-Rong Wen、Ming Li

  DOI：10.1016/j.cclet.2015.07.022

  日期：2015.10

  Abstract The coupling reactions of simple methyl ketones with o -bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.

  摘要实现了简单的甲基酮与邻溴代苯乙酮的偶联反应以及随后的环化反应，从而生成了一系列的1-萘酚。这些级联反应是由稀有的铜催化的甲基酮与芳族溴化物的芳基化反应引发的。
• Process For Producing Phosphonitrilic Acid Ester
  申请人：Kuwata Kotaro

  公开号：US20080091050A1

  公开（公告）日：2008-04-17

  A process for producing a cyclic and/or linear phosphonitrilic acid ester from a cyclic and/or linear phosphonitrile dichloride is provided, wherein the reaction time is shorter and the content of monochloro phosphazenes is very small. When phosphonitrile dichloride is reacted with a metal arylolate and/or a metal alcoholate in the presence of a reaction solvent, a metal arylolate and/or a metal alcoholate composed of at least two different metals having different ionization energies is used and also a specific compound is used as a catalyst.

  解决的问题：提供一种从环状和/或线性磷酸腈二氯化物制备环状和/或线性磷氮酸酯的方法，其中反应时间较短，单氯磷氮烷的含量非常小。 解决方案：当磷酸腈二氯化物与金属芳酚醇盐和/或金属醇盐在反应溶剂存在下反应时，使用由至少两种具有不同电离能的金属组成的金属芳酚醇盐和/或金属醇盐，并且还使用特定化合物作为催化剂。
• POLYMER ELECTROLYTE COMPOSITION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2192597A1

  公开（公告）日：2010-06-02

  Disclosed is a polymer electrolyte composition containing components (A) and (B). (A) a polymer electrolyte containing a segment having an ion-exchange group and a segment having substantially no ion-exchange groups, which is obtained using block copolymerization or graft copolymerization as a copolymerization method (B) a condensate of a phenol and an aldehyde compound

  本发明公开了一种聚合物电解质组合物，其中包含成分(A)和(B)。(A) 含有具有离子交换基团的区段和基本上没有离子交换基团的区段的聚合物电解质，该聚合物电解质采用嵌段共聚或接枝共聚作为共聚方法 (B) 苯酚和醛化合物的缩合物
• Novel photochemical reactions of 1- and 2-naphthols with ethylene promoted by aluminum halides
  作者：Kiyomi Kakiuchi、Bunji Yamaguchi、Masahiko Kinugawa、Masaki Ue、Yoshito Tobe、Yoshinobu Odaira

  DOI：10.1021/jo00062a024

  日期：1993.5

  Novel photoreactions of 1- and 2-naphthols with ethylene promoted by aluminum halides are described. Irradiation of 2-naphthol (2a) with AlX3 (X = Cl, Br) and ethylene in CH2Cl2 gave the corresponding [2 + 2] cycloadduct 7a in good yields. The major side product was 2-ethyl-1-naphthol (8a). Of the Lewis acids and alkenes examined, only AlCl3 and AlBr3 effected the reaction and only ethylene gave satisfactory results, although allene can also be employed. Naphthols 2b-e having different electron-attracting substituents on C-6 afforded [2 + 2] adducts 7b-e in moderate to good yields, while the reactions of C-3-alkyl-substituted derivatives 8a and 15b were unsuccessful. By contrast, 1-naphthol (1a) and its derivatives 1b-e exhibited diverse reactivities depending on the substituent on C-2, C-3, or C-6. Namely 1a and 3-methyl derivative 1b afforded [2 + 2] cycloadducts 16a and 16b in moderate yields. On the other hand, 2-methyl and 2-propyl derivatives 1c and 1d yielded unusual products like indenones 22a and 22b and cyclopropyl ketones 23a and 23b, respectively. 6-Methoxy derivative 1e also gave indenone 30. Plausible reaction mechanisms leading to the observed products are presented.