3-α-acetoxy-7-keto-5β-cholanic acid | 118206-29-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-α-acetoxy-7-keto-5β-cholanic acid
• 英文别名: 3α-acetoxy-7-oxo-5β-cholanoic acid-(24)；3α-Acetoxy-7-oxo-5β-cholansaeure-(24)；(4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3-acetyloxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
• CAS: 118206-29-4
• 化学式: C₂₆H₄₀O₅
• 分子量: 432.601
• InChiKey: PGPIQCADKBSNGJ-LCTUYZRSSA-N

物化性质

• 沸点：
  552.7±25.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-α-acetoxy-7-keto-5β-cholanic acid 在 盐酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.5h， 生成 3-α-acetoxy-6-ethylene-7-keto-5β-cholanic acid
  参考文献：
  名称：

  一种制备奥贝胆酸中间体的方法

  摘要：

  本发明公开了一种以7‑氧代‑石胆酸（II）为原料制备奥贝胆酸重要中间体3‑α‑羟基‑6‑亚乙基‑7‑酮基‑5‑β‑胆烷酸（I）及其衍生物（IA）的方法，（II）经3位羟基或3位羟基及24位羧基保护或直接未进行任何保护、进一步与乙醛通过羟醛缩合反应从而得到3‑α‑羟基‑6‑亚乙基‑7‑酮基‑5‑β‑胆烷酸（I）及其衍生物，用于制备奥贝胆酸，本发明步骤简单，收率较高，适合工业化生产。

  公开号：

  CN105585603B
• 作为产物：
  描述：

  熊去氧胆酸 在 chromium(VI) oxide 、 sodium acetate 、 溶剂黄146 作用下， 生成 3-α-acetoxy-7-keto-5β-cholanic acid
  参考文献：
  名称：

  Serum leptin levels are not influenced by arginine and insulin infusion and by acute changes of GH

  摘要：

  The aim of this study was to evaluate the relationship between GH and leptin in a group of short children and adolescents. Leptin and GH serum levels were measured before and during pharmacological stimulation tests (arginine and insulin) in a group of 45 children (30 male, 15 female), mean age 8.6+/-3.9 yr, affected by idiopathic isolated GH deficiency (GHD), and in a group of 27 children (115 male, 12 female), age 10.9 +/- 3.3 yr, with constitutional growth delay. Results showed that basal and peak leptin levels as well as the AUC were significantly higher in GHD patients compared to controls (p<0.05) and correlated with BMI SDS (p<0.0001) in GHD patients. No change in leptin serum levels was observed during either stimulation test. No correlation was found, however, between basal leptin serum levels and basal, peak and the AUC of GH during the tests. Moreover, no correlation was found between the acute changes of serum GH concentration during both stimulation tests and leptin serum levels. The results suggest that leptin and GH secretion is not correlated and that leptin serum levels mainly reflect the amount of fat tissue, which is higher in GHD patients.

  DOI：

  10.1007/bf03345510

文献信息

• Imai, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1937, vol. 248, p. 65,68
  作者：Imai

  DOI：——

  日期：——