2-((2,4-dinitrophenoxy)methyl)-1-methyl-5-nitro-1H-imidazole | 60768-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((2,4-dinitrophenoxy)methyl)-1-methyl-5-nitro-1H-imidazole
• 英文别名: 1-methyl-2-(2,4-dinitrophenoxymethyl)-5-nitro-imidazole；2-[(2,4-Dinitrophenoxy)methyl]-1-methyl-5-nitroimidazole
• CAS: 60768-37-8
• 化学式: C₁₁H₉N₅O₇
• 分子量: 323.222
• InChiKey: XZNXMCVJHMXTBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  165
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,4-二硝基酚 、 2-(氯甲基)-1-甲基-5-硝基咪唑 生成 2-((2,4-dinitrophenoxy)methyl)-1-methyl-5-nitro-1H-imidazole
  参考文献：
  名称：

  1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles and process for their

  摘要：

  1-烷基-2-(苯氧甲基)-5-硝基咪唑类化合物的制备方法被描述，这些化合物对滴虫和阿米巴活性，并且特别适用于治疗阴道滴虫病。

  公开号：

  US04031232A1

文献信息

• [EN] NOVEL PHENYL DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE PHÉNYLE
  申请人：GENCIA CORP

  公开号：WO2018129258A1

  公开（公告）日：2018-07-12

  The present application provides a novel phenyl derivative, 5-[(2,4- dinitrophenoxy)methyl]-l-methyl-2-nitro-lH-imidazole or a pharmaceutically acceptable salt thereof, which is useful for regulating mitochondria activity, reducing adiposity, treating diseases including diabetes and diabetes-associated complications.

  这份申请提供了一种新型苯基衍生物，5-[(2,4-二硝基苯氧基)甲基]-1-甲基-2-硝基-1H-咪唑或其药用可接受的盐，可用于调节线粒体活性，减少脂肪堆积，治疗包括糖尿病和糖尿病相关并发症在内的疾病。
• Phenyl derivatives
  申请人：Rivus Pharmaceuticals, Inc.

  公开号：US10618875B2

  公开（公告）日：2020-04-14

  The present application provides a novel phenyl derivative, 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole or a pharmaceutically acceptable salt thereof, which is useful for regulating mitochondria activity, reducing adiposity, treating diseases including diabetes and diabetes-associated complications.

  本申请提供了一种新型苯基衍生物--5-[(2,4-二硝基苯氧基)甲基]-1-甲基-2-硝基-1H-咪唑或其药学上可接受的盐，可用于调节线粒体活性、减少脂肪、治疗包括糖尿病和糖尿病相关并发症在内的疾病。
• NOVEL PHENYL DERIVATIVES
  申请人：Rivus Pharmaceuticals, Inc.

  公开号：EP3565806A1

  公开（公告）日：2019-11-13
• Novel Phenyl Derivatives
  申请人：Rivus Pharmaceuticals, Inc.

  公开号：US20190337903A1

  公开（公告）日：2019-11-07

  The present application provides a novel phenyl derivative, 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole or a pharmaceutically acceptable salt thereof, which is useful for regulating mitochondria activity, reducing adiposity, treating diseases including diabetes and diabetes-associated complications.
• Phenyl Derivatives
  申请人：Rivus Pharmaceuticals, Inc.

  公开号：US20210238144A1

  公开（公告）日：2021-08-05

  The present application provides a novel phenyl derivative, 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole or a pharmaceutically acceptable salt thereof, which is useful for regulating mitochondria activity, reducing adiposity, treating diseases including diabetes and diabetes-associated complications.