tert-butyl 4-[(3-(N,N-dimethylcarbamimidoyl)guanidino)methyl]phenyl carbamate | 1108717-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 4-[(3-(N,N-dimethylcarbamimidoyl)guanidino)methyl]phenyl carbamate
• 英文别名: tert-butyl 4-[(3-(N,N-dimethylcarbamimidoyl)guanidino)methyl]phenyl-carbamate；tert-Butyl4-[(3 (N,N-Dimethylcarbamimidoyl)guanidino)methyl]phenyl-carbamate；tert-butyl N-[4-[[[amino-[[amino(dimethylamino)methylidene]amino]methylidene]amino]methyl]phenyl]carbamate
• CAS: 1108717-21-0
• 化学式: C₁₆H₂₆N₆O₂
• 分子量: 334.421
• InChiKey: FESXLDPELYGZCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-{[3-(N,N-Dimethylcarbamimidoyl)guanidino]methyl}phenyl-octanoate 、 4-{[3-(N,N Dimethylcarbamimidoyl)guanidino]methyl}phenyl-diethylcarbamate 生成 tert-butyl 4-[(3-(N,N-dimethylcarbamimidoyl)guanidino)methyl]phenyl carbamate
  参考文献：
  名称：

  TREATMENT OF MUSCLE DISEASE CHARACTERIZED BY INSULIN RESISTANCE

  摘要：

  本文报道了某些肌肉疾病和状况，包括肌肉萎缩症的形式，其特征是肌肉组织中的胰岛素依赖性信号传导受损，本质上是一种胰岛素抵抗形式。本公开涉及治疗剂、组合物和方法，用于治疗肌肉疾病或状况，其特征是通过靶向缺陷胰岛素信号通路的组分来治疗。可以通过给予激活胰岛素信号通路的治疗剂来治疗该疾病或状况，特别是作用于胰岛素受体后来调节细胞内效应分子的治疗剂。一个示例调节剂是二甲双胍。二甲双胍可以单独给予或与另一种用于治疗肌肉疾病或状况的治疗剂一起给予，例如皮质类固醇。

  公开号：

  US20120065176A1

文献信息

• FATTY ACID GUANIDINE AND SALICYLATE GUANIDINE DERIVATIVES AND THEIR USES
  申请人：Milne Jill C.

  公开号：US20120277305A1

  公开（公告）日：2012-11-01

  The invention relates to fatty acid guanidine or salicylate guanidine derivatives; compositions comprising an effective amount of a fatty acid guanidine or salicylate guanidine derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid guanidine or salicylate guanidine derivative.

  这项发明涉及脂肪酸胍或水杨酸胍衍生物；包含有效量脂肪酸胍或水杨酸胍衍生物的组合物；以及治疗或预防代谢性疾病的方法，包括给予有效量脂肪酸胍或水杨酸胍衍生物。
• Towards Metformin Prodrugs
  作者：Kristiina Huttunen、Jukka Leppänen、Eeva Kemppainen、Piia Palonen、Jarkko Rautio、Tomi Järvinen、Jouko Vepsäläinen

  DOI：10.1055/s-0028-1083603

  日期：2008.11

  The first examples of possible metformin prodrugs have been synthesized and characterized by spectroscopic methods. These five different types of chemically stable prodrugs were prepared from metformin and the corresponding halogenated promoieties. The products from unstable derivatives were also identified and reasons for the rearrangements are discussed.

  我们合成了第一批可能的二甲双胍原药，并通过光谱方法对其进行了表征。这五种不同类型的化学性质稳定的原药是由二甲双胍和相应的卤化原基制备的。此外，还确定了不稳定衍生物的产物，并讨论了重排的原因。
• Treatment of muscle disease characterized by insulin resistance
  申请人：Megeney Lynn

  公开号：US08993633B2

  公开（公告）日：2015-03-31

  It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The present disclosure relates to therapeutic agents, compositions and methods for treating a muscle disease or condition characterized by impaired insulin-dependent signaling by targeting components of the defective insulin signaling pathway. The disease or condition may be treated by administering a therapeutic agent that activates the insulin signaling pathway, in particular, therapeutic agents that act post-insulin receptor to modulate intracellular effector molecules. An exemplary modulator is metformin. Metformin may be administered alone or may be coadministered with another therapeutic agent for treating the muscle disease or condition, such as a corticosteroid.

  本文报道了某些肌肉疾病和情况，包括肌肉萎缩症的形式，其特征是肌肉组织中的胰岛素依赖性信号传导受损，本质上是一种胰岛素抵抗形式。本公开涉及治疗剂、组合物和方法，用于通过针对缺陷的胰岛素信号途径的组分来治疗被胰岛素依赖性信号传导受损所特征的肌肉疾病或情况。可以通过给予激活胰岛素信号途径的治疗剂来治疗疾病或情况，特别是作用于胰岛素受体后来调节细胞内效应分子的治疗剂。一个示例调节剂是二甲双胍。二甲双胍可以单独给予，也可以与用于治疗肌肉疾病或情况的另一种治疗剂如皮质类固醇一起联合给予。
• Combined Pharmaceutical Preparation for Use in Treating Neuromuscular Disorders
  申请人：Universitäts-Kinderspital beider Basel

  公开号：EP2837390A1

  公开（公告）日：2015-02-18

  The present invention relates to a combined pharmaceutical preparation for use in a method for preventing or treating muscular dystrophy, comprising an activator of neuronal nitric oxide synthase, and a nitric oxide precursor, wherein said nitric oxide precursor is convertible by said nitric oxide synthase to nitric oxide

  本发明涉及一种用于预防或治疗肌肉萎缩症方法的组合药物制剂，包括神经元一氧化氮合酶激活剂和一氧化氮前体，其中所述一氧化氮前体可通过所述一氧化氮合酶转化为一氧化氮
• US8993633B2
  申请人：——

  公开号：US8993633B2

  公开（公告）日：2015-03-31