trans-4-[4-(2,4-dioxo-1,4-dihydroquinazolin-3-ylmethyl)cyclohexanecarbonyl]piperazine-1-carboxylic acid tert-butyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: trans-4-[4-(2,4-dioxo-1,4-dihydroquinazolin-3-ylmethyl)cyclohexanecarbonyl]piperazine-1-carboxylic acid tert-butyl ester
• 英文别名: 4-[trans-4-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl)cyclohexanecarbonyl]-piperazine-1-carboxylic acid tert-butyl ester；tert-butyl 4-[4-[(2,4-dioxo-1H-quinazolin-3-yl)methyl]cyclohexanecarbonyl]piperazine-1-carboxylate
• 化学式: C₂₅H₃₄N₄O₅
• 分子量: 470.569
• InChiKey: DKZNEKIHGOUTTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  99.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  trans-4-[4-(2,4-dioxo-1,4-dihydroquinazolin-3-ylmethyl)cyclohexanecarbonyl]piperazine-1-carboxylic acid tert-butyl ester 在 硫酸 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 生成 trans-3-[4-(4-cyclopropanecarbonylpiperazine-1-carbonyl)cyclohexylmethyl]-1H-quinazoline-2,4-dione
  参考文献：
  名称：

  Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway

  摘要：

  Wnt signaling pathway plays a critical role in numerous cellular processes, including tumor initiation, proliferation, invasion/infiltration, metastasis formation and resistance to chemotherapy. In a drug discovery project aimed at the identification of inhibitors of the canonical Wnt pathway, we selected a series of quinazoline 2,4-diones as starting point for the therapeutic treatment of glioblastoma multiforme. Despite of poor physico-chemical properties of hit compound I, our medicinal chemistry effort allowed the discovery and characterization of lead compound 33 (SEN461), with improved ADME profile, good bioavailability and active in vitro and in vivo in glioblastoma, gastric and sarcoma tumors. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.03.055
• 作为产物：
  描述：

  trans-4-aminomethyl-cyclohexanecarboxylic acid methyl ester 在 水 、 potassium carbonate 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 lithium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 54.0h， 生成 trans-4-[4-(2,4-dioxo-1,4-dihydroquinazolin-3-ylmethyl)cyclohexanecarbonyl]piperazine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway

  摘要：

  Wnt signaling pathway plays a critical role in numerous cellular processes, including tumor initiation, proliferation, invasion/infiltration, metastasis formation and resistance to chemotherapy. In a drug discovery project aimed at the identification of inhibitors of the canonical Wnt pathway, we selected a series of quinazoline 2,4-diones as starting point for the therapeutic treatment of glioblastoma multiforme. Despite of poor physico-chemical properties of hit compound I, our medicinal chemistry effort allowed the discovery and characterization of lead compound 33 (SEN461), with improved ADME profile, good bioavailability and active in vitro and in vivo in glioblastoma, gastric and sarcoma tumors. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.03.055

文献信息

• [EN] WNT PATHWAY ANTAGONISTS<br/>[FR] ANTAGONISTES DE LA VOIE WNT
  申请人：SIENA BIOTECH SPA

  公开号：WO2011042145A1

  公开（公告）日：2011-04-14

  The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer.

  本发明涉及如下所述的已知和新颖的化合物（I）的公式及其药物组成。公式（I）的化合物对Wnt途径具有抑制作用，因此在制备药物方面特别适用于治疗癌症。
• WNT PATHWAY ANTAGONISTS
  申请人：Varrone Maurizio

  公开号：US20120196851A1

  公开（公告）日：2012-08-02

  The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer.

  本发明涉及公知和新颖的化合物(I)及其药物组合物。化合物(I)对Wnt通路具有抑制作用，因此在制备药物中特别适用于癌症的治疗。
• US8865704B2
  申请人：——

  公开号：US8865704B2

  公开（公告）日：2014-10-21
• Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway
  作者：Arianna Nencini、Carmela Pratelli、Joanna M. Quinn、Massimiliano Salerno、Patrizia Tunici、Alessandra De Robertis、Silvia Valensin、Federica Mennillo、Marco Rossi、Annette Bakker、Tiziana Benicchi、Federico Cappelli、Elisa Turlizzi、Martina Nibbio、Nicola P. Caradonna、Ugo Zanelli、Matteo Andreini、Matteo Magnani、Maurizio Varrone

  DOI：10.1016/j.ejmech.2015.03.055

  日期：2015.5

  Wnt signaling pathway plays a critical role in numerous cellular processes, including tumor initiation, proliferation, invasion/infiltration, metastasis formation and resistance to chemotherapy. In a drug discovery project aimed at the identification of inhibitors of the canonical Wnt pathway, we selected a series of quinazoline 2,4-diones as starting point for the therapeutic treatment of glioblastoma multiforme. Despite of poor physico-chemical properties of hit compound I, our medicinal chemistry effort allowed the discovery and characterization of lead compound 33 (SEN461), with improved ADME profile, good bioavailability and active in vitro and in vivo in glioblastoma, gastric and sarcoma tumors. (C) 2015 Elsevier Masson SAS. All rights reserved.