2-Butyl-6-(butylamino)benzo[de]isoquinoline-1,3-dithione | 1402816-83-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Butyl-6-(butylamino)benzo[de]isoquinoline-1,3-dithione
• 英文别名: 2-butyl-6-(butylamino)benzo[de]isoquinoline-1,3-dithione
• CAS: 1402816-83-4
• 化学式: C₂₀H₂₄N₂S₂
• 分子量: 356.556
• InChiKey: XPVGGVBPPUAVSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  79.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  溶剂黄43 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 18.0h， 生成 2-Butyl-6-(butylamino)benzo[de]isoquinoline-1,3-dithione
  参考文献：
  名称：

  用于癌症光动力疗法的高效无重原子光敏剂的设计与合成。

  摘要：

  合成并研究了具有优异ROS生成能力的新型硫代羰基衍生物（NIS和CRNS），作为用于单光子和双光子激发光动力疗法的潜在光敏剂。尤其是，NIS-Me和CRNS在双光子激发（800 nm）下对HeLa细胞表现出出色的光毒性，而暗毒性却可以忽略不计。

  DOI：

  10.1039/d0cc04644b

文献信息

• Synthesis of thionaphthalimides and their dual Hg2+-selective signaling by desulfurization of thioimides
  作者：Jung Ok Moon、Myung Gil Choi、Taihao Sun、Jong-In Choe、Suk-Kyu Chang

  DOI：10.1016/j.dyepig.2012.08.007

  日期：2013.1

  A series of new thionaphthalimide derivatives were prepared, and their Hg2+-selective signaling behavior was investigated in aqueous acetonitrile solution. A monothionaphthalimide (anti) exhibited pronounced Hg2+-selective chromogenic signaling behavior through a solution color change from red to yellow, which was easily detectable by eye. It (anti) also showed prominent off-on type Hg2+-selective fluorescent signaling behavior. The signaling is due to the Hg2+-assisted desulfurization of the thioimide to its imide structure. The presence of other common metal ions did not interfere with the Hg2+-signaling of the monothionaphthalimide (anti). The detection limit of monothionaphthalimide (anti) for the determination of Hg2+ ions in 30% aqueous acetonitrile was estimated to be 2.7 mu M. (C) 2012 Elsevier Ltd. All rights reserved.