无水氯化铜 | 7447-39-4

• 物质功能分类: 无机化工 - 无机盐 - 金属卤化物及卤酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 中文名称: 无水氯化铜
• 中文别名: 二氯化铜；无水氯化铜(Ⅱ)；氯化铜(II)；氯化铜；氯化铜无水；氯化铜(无水)；无水氯化铜(II)
• 英文名称: copper(II) chloride
• 英文别名: Cucl2；copper chloride；Cupric chloride；Copper;dichloride
• CAS: 7447-39-4
• 化学式: Cl₂Cu
• 分子量: 134.452
• InChiKey: ORTQZVOHEJQUHG-UHFFFAOYSA-L

物化性质

• 熔点：
  620 °C(lit.)
• 沸点：
  993°C/760mmHg
• 密度：
  3.386 g/mL at 25 °C(lit.)
• 溶解度：
  可溶于水中
• 暴露限值：
  ACGIH: TWA 1 mg/m3NIOSH: IDLH 100 mg/m3; TWA 1 mg/m3
• 表面张力：
  72.7mN/m at 1.01g/L and 21℃
• 物理描述：
  Copper chloride appears as a yellowish-brown powder (the anhydrous form) or a green crystalline solid (the dihydrate). Noncombustible but hydrogen chloride gas may form when heated in a fire. Corrosive to aluminum. Used to manufacture other chemicals, in dyeing, in printing, in fungicides, as a wood preservative.
• 颜色/状态：
  Yellow to brown, microcrystalline powder
• 稳定性/保质期：
  1. 如果遵照规格使用和储存，则不会分解。 2. 无水氯化铜在993℃时分解为氯化亚铜；氯化铜易溶于水及乙醇，也溶于丙酮。
• 分解：
  993 °C DECOMP TO CUPROUS CHLORIDE
• 腐蚀性：
  It is corrosive to aluminum.

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

铜主要通过胃肠道吸收，但也可以通过吸入和皮肤吸收。它通过基底外侧膜，可能是通过调节铜转运蛋白，并与血清白蛋白结合被运输到肝脏和肾脏。肝脏是铜稳态的关键器官。在肝脏和其他组织中，铜以与金属硫蛋白、氨基酸以及与依赖铜的酶结合的形式储存，然后分配通过胆汁排泄或并入细胞内和细胞外蛋白中。铜通过血浆中与血清白蛋白、铜蓝蛋白或低分子量复合物结合的方式被运输到外周组织。铜可能诱导金属硫蛋白和铜蓝蛋白的产生。膜结合的铜转运腺苷三磷酸酶（Cu-ATPase）将铜离子输送到细胞内和细胞外。体内生理正常水平的铜通过改变铜的吸收速率和数量、分布区域以及排泄来保持恒定。(L277, L279)

Copper is mainly absorbed through the gastrointestinal tract, but it can also be inhalated and absorbed dermally. It passes through the basolateral membrane, possibly via regulatory copper transporters, and is transported to the liver and kidney bound to serum albumin. The liver is the critical organ for copper homoeostasis. In the liver and other tissues, copper is stored bound to metallothionein, amino acids, and in association with copper-dependent enzymes, then partitioned for excretion through the bile or incorporation into intra- and extracellular proteins. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular-weight complexes. Copper may induce the production of metallothionein and ceruloplasmin. The membrane-bound copper transporting adenosine triphosphatase (Cu-ATPase) transports copper ions into and out of cells. Physiologically normal levels of copper in the body are held constant by alterations in the rate and amount of copper absorption, compartmental distribution, and excretion. (L277, L279)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

过量的铜被储存在肝细胞溶酶体中，在那里它与金属硫蛋白结合。当溶酶体饱和，铜在细胞核中积累，导致核损伤时，铜的肝毒性被认为会发生。这种损伤可能是由于氧化损伤，包括脂质过氧化。铜抑制了诸如葡萄糖-6-磷酸1-脱氢酶、谷胱甘肽还原酶和对氧磷酶等含有巯基团的酶，这些酶保护细胞免受自由氧自由基的侵害。它还影响基因表达，并且是诸如细胞色素C氧化酶和赖氨氧化酶等氧化酶的辅因子。此外，由铜引起的氧化应激被认为会激活酸性鞘磷脂酶，导致神经酰胺的产生，这是一种凋亡信号，同时也会引起溶血性贫血。铜诱导的呕吐是由于迷走神经的刺激所致。

Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. (L277, T49, A174, L280)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 药物性肝损伤

化合物：氯化铜

Compound:cupric chloride

来源:Drug Induced Liver Injury Rank (DILIrank) Dataset

毒理性

• 药物性肝损伤

DILI 注释：无 DILI（药物性肝损伤）担忧

DILI Annotation:No-DILI-Concern

来源:Drug Induced Liver Injury Rank (DILIrank) Dataset

毒理性

• 药物性肝损伤

标签部分：无匹配

Label Section:No match

来源:Drug Induced Liver Injury Rank (DILIrank) Dataset

毒理性

• 药物性肝损伤

参考文献：M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. 美国食品药品监督管理局批准的药物标签用于研究药物诱导的肝损伤，《药物发现今日》，16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007 M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank：按人类发展药物诱导肝损伤风险排名的最大参考药物清单。《药物发现今日》2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015

References:M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007 M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015

来源:Drug Induced Liver Injury Rank (DILIrank) Dataset

吸收、分配和排泄

• 吸收

口服给予四名志愿者0.4-4.5毫克铜（以醋酸铜形式）后，平均铜吸收率为57％（范围在40至70％之间）。早期的一项人体研究表明，口服氯化铜（1.5-12毫克铜）后约两小时达到最大血铜浓度。

Mean copper absorption of 57 percent (range 40 to 70 per cent) following oral administration of 0.4 - 4.5 mg copper (as copper acetate) to four volunteers. An early human study suggested a maximum blood copper concentration was reached some two hours after oral copper chloride administration (1.5 - 12 mg copper)

来源:DrugBank

吸收、分配和排泄

• 消除途径

肾脏的

Renal

来源:DrugBank

吸收、分配和排泄

• 分布容积

铜被分布到所有组织中，以肝脏、心脏、大脑、肾脏和肌肉中的浓度最高。细胞内铜主要与金属硫蛋白结合。据报道，在肺、肝、肾、血液、胆汁和胃中的铜含量分别为（每克湿重）：33.7、35.1、41.4、13.8、2.8和2988微克。

Copper is distributed to all tissues with the highest concentrations in liver, heart, brain, kidneys and muscle. Intracellular copper is predominantly metallothionein-bound. Reported copper in the lungs, liver, kidney, blood, bile and stomach (33.7, 35.1, 41.4, 13.8, 2.8, and 2988 µg/g wet weight respectively)

来源:DrugBank

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 危险品标志：
  T
• 安全说明：
  S26,S29,S36,S37/39,S45,S57,S60,S61
• 危险类别码：
  R36/37/38,R25,R50/53
• WGK Germany：
  2
• 海关编码：
  28274990
• 危险品运输编号：
  UN 3264 8/PG 3
• 危险类别：
  8
• RTECS号：
  GL7000000
• 包装等级：
  III
• 储存条件：
  密封在阴凉干燥的环境中。

SDS

Name:	Copper(II) Chloride Anhydrous 98% Material Safety Data Sheet
Synonym:	Cupric Chloride
CAS:	7447-39-4

Section 1 - Chemical Product MSDS Name:Copper(II) Chloride Anhydrous 98% Material Safety Data Sheet
Synonym:Cupric Chloride

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7447-39-4	Copper(II) Chloride, Anhydrous, 98%	98%	231-210-2

Hazard Symbols: XN
Risk Phrases: 22 36

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation. May result in corneal injury. Causes redness and pain.
Skin:
May cause skin irritation. Causes redness and pain.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage.
Inhalation:
Dust is irritating to the respiratory tract. May cause severe irritation of the upper respiratory tract with pain, burns, and inflammation. May be harmful if inhaled.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. May cause liver and kidney damage.

---

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
Substance is noncombustible.
Extinguishing Media:
Substance is noncombustible; use agent most appropriate to extinguish surrounding fire.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Use only in a well-ventilated area. Minimize dust generation and accumulation.
Do not breathe dust, vapor, mist, or gas. Do not get on skin or in eyes. Do not ingest or inhale.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 7447-39-4: United Kingdom, WEL - TWA: (listed as copper): 0.2 mg/m3 TWA (fum 1 mg/m3 TWA (dust and mist) United Kingdom, WEL - STEL: (listed as copper): 0.6 mg/m3 STEL (fume); 2 mg/m3 STEL (dust and mist) United States OSHA: 0.1 mg/m3 TWA (fume); 1 mg/m3 TWA (dusts and mists) (listed under Copper).
Belgium - TWA: (listed as copper): 0.2 mg/m3 VLE (fume); 1 mg/m3 (dust and mist) France - VME: (listed as copper): 0.2 mg/m3 VME (fume); 1 mg/m3 V (dust, as Cu) France - VLE: (listed as copper): 2 mg/m3 VLE (dust, as Cu) Germany: (listed as copper): 0.2 mg/m3 VME (fume); 1 mg/m3 VME (d as Cu) Malaysia: (listed as copper): 0.2 mg/m3 TWA (fume, as Cu); 1 mg/m TWA (dust and mist, as Cu) Netherlands: (listed as copper): 0.2 mg/m3 MAC (smoke); 1 mg/m3 M (dust) Russia: (listed as copper): 1 mg/m3 TWA (dust) Russia: (listed as copper): 0.5 mg/m3 STEL (dust) Spain: (listed as copper): 0.2 mg/m3 VLA-ED (fume); 1 mg/m3 VLA-E (dust and mist, as Cu) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: brown
Odor: Odorless.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 993 deg C @ 760.00mm Hg
Freezing/Melting Point: 620 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: >300 deg C
Solubility in water: soluble
Specific Gravity/Density: 3.3860g/cm3
Molecular Formula: Cl2Cu
Molecular Weight: 134.45

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, heating to decomposition, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture, alkali metals, potassium, sodium, nitromethane, hydrazine, and sodium hypobromite.
Hazardous Decomposition Products:
Hydrogen chloride.
Hazardous Polymerization: Will not occur.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7447-39-4: GL7000000 LD50/LC50:
CAS# 7447-39-4: Oral, mouse: LD50 = 233 mg/kg; Oral, rat: LD50 = 584 mg/kg; Oral, rat: LD50 = 140 mg/kg.
Carcinogenicity:
Copper(II) Chloride, Anhydrous, 98% - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

---

Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fishtoxicity: Strickleback exposed to 2 mg/l (CuCl2) died within 16-24 hr, and steelhead trout and sockeye salmon died in 12-16 hr.
Bridgelip sucker exposed to 3 mg/l died within 12-18 hr. (Macphee, C.
et al Fish Toxicity Screening Date 1989, Parts 1 and 2, EPA 560/6-89-001, PB 89-156715, Washington, DC) Invertebrate toxicity: The crab Scylla serrata was exposed to 10, 50 and 100 mg/l (Cu2+) for 14 days. The mortality rates were 60, 100 and 100%, respectively. (Arumugam, M. et al Bull. Environ. Contam. Toxicol.
1987, 39(4), 708-715)

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: COPPER CHLORIDE
Hazard Class: 8
UN Number: 2802
Packing Group: III
IMO
Shipping Name: COPPER CHLORIDE
Hazard Class: 8
UN Number: 2802
Packing Group: III
RID/ADR
Shipping Name: COPPER CHLORIDE
Hazard Class: 8
UN Number: 2802
Packing group: III
USA RQ: CAS# 7447-39-4: 10 lb final RQ; 4.54 kg final RQ

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 39 Wear eye/face protection.
WGK (Water Danger/Protection)
CAS# 7447-39-4: 2
Canada
CAS# 7447-39-4 is listed on Canada's DSL List.
CAS# 7447-39-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7447-39-4 is listed on the TSCA inventory.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

理化性质

氯化铜的化学式为CuCl₂，是一种黄棕色粉末，相对密度为3.386（25℃），熔点为620℃。在0℃时其溶解度为70.6克/100毫升水，易溶于乙醇和丙酮。该物质容易从空气中吸湿而变成蓝绿色的二水合物CuCl₂·2H₂O。二水合物是一种绿色斜方晶体，具有潮解性，相对密度为2.38。可通过将氯气和水通入装有金属铜的接触塔中制备，或用碳酸铜（实际是碱式碳酸铜）和盐酸作用来制取。此水合物在110℃下失水，而无水氯化铜可在氯化氢气流中于140～150℃条件下制得。进一步加热到993℃时，无水氯化铜会分解为白色氯化亚铜和氯气。X射线研究证实，氯化铜是一种共价化合物，呈现平面链状结构。

浓的氯化铜溶液呈现黄绿色，在浓溶液中显绿色，在稀溶液中则呈蓝色。黄色来源于[CuCl]²⁻配位离子的存在，而蓝色则是由于[Cu(H₂O)₄]²⁺配位离子存在，二者共存时显现出绿色。氯化铜常被用作许多有机反应（如烃的氯化反应）的催化剂、石油产品的脱色剂和脱硫剂，以及木材防腐剂、织物印染中的媒染剂、消毒剂、饲料添加剂和玻璃、陶瓷的颜料。

化学反应

氯化铜与浓盐酸反应生成四氯合铜(Ⅱ) 酸；与碱金属氯化物反应则生成M₂[CuCl₄]型配盐。将过量的氯气通过赤热的铜，可得无水盐；氧化铜溶于浓盐酸后，经浓缩、结晶，则得到二水合物。

氯化铜与氨作用形成深蓝色的铜氨配合物Cu(NH₃)；与强碱作用则生成淡蓝色的氢氧化铜Cu(OH)₂絮状沉淀；与还原性阴离子如I⁻、CN⁻等反应时，会形成碘化亚铜CuI白色沉淀和Cu(CN)配合物。

在碱性溶液中，氯化铜可被葡萄糖等还原剂还原成红色的氧化亚铜：2Cu²⁺ + 4OH⁻ + C₆H₁₂O₆ → Cu₂O + 2H₂O + C₆H₁₂O₇。此反应可用于检验糖尿病。

用途

氯化铜用作化学试剂、媒染剂、氧化剂、木材防腐剂、食品添加剂和消毒剂，也用于石油馏分的脱臭和脱硫、金属提炼、照相等。

制备方法

氯化铜可通过盐酸作用于氧化铜CuO或碳酸铜（实际是碱式碳酸铜Cu(OH)₂·CuCO₃）而制得。

生产方法

1. 将纯的二水合氯化铜CuCl₂·2H₂O用稀盐酸重结晶，以除去其中的碱式盐。将其置于干燥的氯化氢气流中，在140～150℃下脱水，直至重量不再减少为止。所得无水物应在盛有浓硫酸和氢氧化钠的干燥器中去除附着在其上的氯化氢。

类别

有毒物质

毒性分级

高毒

急性毒性

• 大鼠 LD₅₀：584毫克/公斤
• 小鼠 LD₅₀：233毫克/公斤

可燃性危险特性

不可燃烧；火场产生有毒含铜、氯化物烟雾。

储运特性

库房低温、通风、干燥，与食品原料分开存放。

灭火剂

水、二氧化碳、干粉、砂土。

职业标准

• 时间加权平均容许浓度（TWA）：0.1毫克/立方米
• 短时间接触容许浓度（STEL）：0.2毫克/立方米

反应信息

• 作为反应物：
  描述：

  无水氯化铜 生成 氯化亚铜
  参考文献：
  名称：

  KRECHMER, G. A.;FEOFILOVA, T. F.;TOPCHIJ, V. A.;ZAGORULKO, V. P.;BATURA, +, MATER. DLYA HOB. TEXN., M.,(1988) S. 110-114

  摘要：

  DOI：
• 作为产物：
  描述：

  氧化铜 生成 无水氯化铜
  参考文献：
  名称：

  MANTASHYAN, A. A.;MARTIROSYAN, V. A.;ZAPROSYAN, A. V., ARM. XIM. ZH., 42,(1989) N, S. 351-356

  摘要：

  DOI：
• 作为试剂：
  描述：

  2’-氨基苯甲酰苯胺 在 tetraethylammonium hexafluorophosphate 、 无水氯化铜 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 28.0h， 生成 1,2-dimethyl-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
  参考文献：
  名称：

  Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

  摘要：

  DOI：

  10.1016/j.cclet.2021.09.019

文献信息

• ANDROGEN RECEPTOR MODULATING CARBOXAMIDES
  申请人：Törmakängas Olli

  公开号：US20140094474A1

  公开（公告）日：2014-04-03

  Compounds of formula (I) or (II) wherein R x , R z , R 9 , R 10 , R 14 , R 14 ′, R 15 , R 15 ′, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

  式(I)或(II)的化合物 其中R x ，R z ，R 9 ，R 10 ，R 14 ，R 14 ′，R 15 ，R 15 ′，A和B如权利要求中所定义，并且其药学上可接受的盐和酯已被披露。这些化合物具有作为组织选择性雄激素受体调节剂（SARM）的效用，并且在治疗前列腺癌和其他依赖于AR的疾病和病症中，需要AR拮抗作用时可用作药物。
• Oxindole derivative
  申请人：Sumitomo Pharmaceuticals Co., Ltd.

  公开号：US06576656B1

  公开（公告）日：2003-06-10

  An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R1, R2, R3 and R4 are independently hydrogen, optionally substituted alkyl etc; R5 is optionally substituted aryl or optionally substituted heteroaryl; Z is —O— or —NH—; one of W1 and W2 is hydrogen, alkyl or —Y—CON(R10)R11; the other of W1 and W2 is n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R6 and R7 are independently hydrogen, optionally substituted alkyl etc; R8 and R9 are independently hydrogen, optionally substituted alkyl etc; R10 and R11 are independently hydrogen, alkyl etc.

  Formula 1的氧吲哚或其前药，或其药学上可接受的盐对生长激素释放剂有用： 其中 R1、R2、R3和R4独立地是氢、可选择地取代的烷基等； R5是可选择地取代的芳基或可选择地取代的杂环芳基； Z是—O—或—NH—； W1和W2中的一个是氢、烷基或—Y—CON(R10)R11； 另一个是 n为1、2或3；m为0、1、2或3； Y是单键或C1-C3烷基； R6和R7独立地是氢、可选择地取代的烷基等； R8和R9独立地是氢、可选择地取代的烷基等； R10和R11独立地是氢、烷基等。
• Acridine derivatives
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0371388A3

  公开（公告）日：1991-01-09

  A compound of the formula : wherein R¹ is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or mono(or di or tri)halo(lower)alkyl, and (in which R² and R³ are each lower alkyl), and a pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with pharmaceutically acceptable carriers. The invention also relates to intermediates of the formula

  该化合物的化学式为： 其中R¹为氢、卤素、羟基、较低的烷氧基、较低的烷基或单(或二或三)卤代(较低)烷基，以及 (其中R²和R³各自为较低的烷基)， 以及其药学上可接受的盐，其制备方法以及包含它们作为活性成分与药学上可接受的载体混合物的药物组合物。该发明还涉及该化合物的中间体的化学式。
• Pyrimidines and uses thereof
  申请人：Cell Therapeutics, Inc.

  公开号：US20040204386A1

  公开（公告）日：2004-10-14

  The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity and/or proliferation of cells such as tumor-cells.

  这项发明涉及嘧啶类化合物及其用途，包括抑制溶磷脂酸酰基转移酶β（LPAAT-β）活性和/或抑制肿瘤细胞等细胞的增殖。
• Derivatives of N-phenylpyrazoles
  申请人：——

  公开号：US05232940A1

  公开（公告）日：1993-08-03

  N-Phenylpyrazole derivatives of the formula: ##STR1## wherein R.sup.1 represents cyano, nitro, halogen, acetyl or formyl; R.sup.2 represents R.sup.5 SO.sub.2, R.sup.5 SO or R.sup.5 S in which R.sup.5 is optionally halogen substituted alkyl, alkenyl or alkynyl; R.sup.3 represents a hydrogen atom or a group NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each represent hydrogen, alkyl, alkenylalkyl, alkynylalkyl, formyl, optionally halogen substituted alkanoyl, optionally halogen substituted alkoxycarbonyl, or alkoxymethyleneamino, halogen, or R.sup.6 and R.sup.7 together form a cyclic imide and R.sup.4 represents a substituted phenyl group possess arthropodicidal, plant nematocidal, anthelmintic and anti-protozoal properties; their preparation, compositions containing them and their use are described.

  N-苯基吡唑衍生物的化学式为：##STR1## 其中R.sup.1代表氰基，硝基，卤素，乙酰基或甲酰基；R.sup.2代表R.sup.5 SO.sub.2，R.sup.5 SO或R.sup.5 S，其中R.sup.5可选择地被卤素取代的烷基，烯基或炔基；R.sup.3代表氢原子或基团NR.sup.6 R.sup.7，其中R.sup.6和R.sup.7各自代表氢，烷基，烯基烷基，炔基烷基，甲酰基，可选择地被卤素取代的烷酰基，可选择地被卤素取代的烷氧羰基，或烷氧亚甲基氨基，卤素，或R.sup.6和R.sup.7一起形成环状亚酰胺，R.sup.4代表取代苯基团，具有杀虫，植物线虫，驱虫和抗原虫药物性质；描述了它们的制备，含有它们的组合物以及它们的用途。

表征谱图