2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl) biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl) biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one
• 化学式: C₂₅H₂₂N₈O₂
• 分子量: 466.502
• InChiKey: IIBBJCNVTRCTDV-QYQHSDTDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.05
• 重原子数：
  35.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  131.75
• 氢给体数：
  3.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl) biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one 、 胆碱 在 三氟乙酸 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 3.5h， 以83%的产率得到2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl) biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
  参考文献：
  名称：

  [EN] 2-(3,4-DIMETHYLPHENYL)-4-{[2-HYDROXY-3'(1H-TETRAZOL-5-YL)BIPHENYL-3-YL]-HYDRAZONO}-5-METHYL-2,4-DIHYDROPYROZOL-3-ONE CHOLINE
  [FR] 2-(3,4-DIMETHYLPHENYL)-4-{[2-HYDROXY-3'(1H-TETRAZOL-5-YL)BIPHENYL-3-YL]-HYDRAZONO}-5-METHYL-2,4-DIHYDROPYRAZOL-3-ONE CHOLINE

  摘要：

  公开号：

  WO2005041867A3

文献信息

• Thrombopoietin mimetics
  申请人：——

  公开号：US20040019190A1

  公开（公告）日：2004-01-29

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy- 1 -azobenzene derivative.

  发明了非肽类TPO类似物。还发明了用于制备目前发明的化合物的新工艺和中间体。还发明了一种治疗血小板减少症的方法，包括给予需要的哺乳动物，包括人类，有效量的选择性羟基-1-偶氮苯衍生物。
• THROMBOPOIETIN MIMETICS
  申请人：Duffy Kevin J.

  公开号：US20090155203A1

  公开（公告）日：2009-06-18

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

  发明了非肽类TPO类似物。还发明了用于制备当前发明化合物的新型过程和中间体。还发明了一种治疗血小板减少症的方法，包括在需要的哺乳动物（包括人类）中给予所述哺乳动物有效量的选择性羟基-1-偶氮苯衍生物。
• 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1h-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
  申请人：Brook S. Christopher

  公开号：US20070072922A1

  公开（公告）日：2007-03-29

  An improved thrombopoietin mimetic, the choline salt of 2-(3,4-dimethylphenyl)-4-[2-hydroxy-3′-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one.

  一种改进的血小板生成素类似物，为2-(3,4-二甲基苯基)-4-[2-羟基-3′-(1H-四唑-5-基)联苯-3-基]-肼基}-5-甲基-2,4-二氢吡唑-3-酮的胆碱盐。
• Methods for treating degenerative diseases/injuries
  申请人：Glaxosmithkline LLC

  公开号：EP2387998A1

  公开（公告）日：2011-11-23

  Invented is a method of treating degenerative diseases/injuries, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal.

  本发明是一种治疗哺乳动物（包括人类）退行性疾病/损伤的方法，该方法包括向哺乳动物施用治疗有效量的非肽类 TPO 受体激动剂。
• Stimulating platelet generation by activating mitochondrial biogenesis
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US10918655B2

  公开（公告）日：2021-02-16

  A method of stimulating platelet formation using a drug that stimulates mitochondrial biogenesis is described. The drug can be used to treat a subject that has been diagnosed with thrombocytopenia or a relatively low platelet count, or it can be used to stimulate platelet generation in vitro or ex vivo. Low-level light (LLL) therapy can be used together with the drug to stimulate mitochondrial biogenesis.

  本文描述了一种使用刺激线粒体生物生成的药物来刺激血小板形成的方法。该药物可用于治疗被诊断为血小板减少症或血小板计数相对较低的患者，也可用于体外或体内刺激血小板生成。低强度光（LLL）疗法可与该药物一起用于刺激线粒体的生物生成。