(+)-O-去甲基曲马多 | 144830-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (+)-O-去甲基曲马多
• 英文名称: (+)-O-Demethyltramadol
• 英文别名: O-desmethyl tramadol；O-Demethyltramadol；(+)-O-Desmethyl-tramadol；(+)-O-desmethyl tramadol；O-desmethyl-cis-tramadol；(+)-O-desmethyltramadol；O-Desmethyltramadol；3-[(1R,2R)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]phenol
• CAS: 144830-14-8
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: UWJUQVWARXYRCG-HIFRSBDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  双氯芬酸 、 (+)-O-去甲基曲马多 在 水 作用下， 以 乙腈 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 以100%的产率得到(+)-O-desmethyl-tramadol diclofenac salt
  参考文献：
  名称：

  Pharmaceutical compounds of O-Desmethyl-Tramadol and COX-inhibitors

  摘要：

  本发明涉及包含O-去甲甲氧基可待因和至少一种COX抑制剂，特别是NSAID的药物化合物，以及其制备方法以及它们作为药物或在制药配方中的用途，更具体地用于治疗疼痛。药物化合物可以是盐或盐的结晶形式或共晶形式。

  公开号：

  EP2281558A1
• 作为产物：
  描述：

  去甲苯胺环醇/(-)-O-去甲基曲马多 在 吡啶 、 pig liver esterase 、 水 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 48.5h， 生成 (+)-O-去甲基曲马多
  参考文献：
  名称：

  Enzymatic resolution of analgesics: δ-hydroxytramadol, ε-hydroxytramadol and O-desmethyltramadol

  摘要：

  Efficient enzymatic resolutions of the analgesic delta-hydroxytramadol rac-3 and epsilon-hydroxytramadol rac-4 have been achieved through pig liver esterase- and Candida rugosa lipase-catalyzed hydrolyses of the corresponding butyrates. The Candicia rugosa lipase-catalyzed hydrolysis of O-desmethyltramadol butyrate rac-8a, having a remote aromatic acyloxy group as the only functional group amendable to a hydrolase-catalyzed reaction, proceeded with a good selectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00008-2

文献信息

• Opioid Detection
  申请人：Randox Laboratories Limited

  公开号：US20170176476A1

  公开（公告）日：2017-06-22

  An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.

  描述了一种免疫分析方法，仅检测O-去甲基曲马多。这使得检测具有高灵敏度和特异性的方法成为可能，避免了假阳性结果。免疫分析方法中所包含的独特抗体可以与检测米特拉吉宁的抗体结合，从而提供一种增加检测常见药物组合O-去甲基曲马多和米特拉吉宁可能性的检测方法。
• [EN] PHARMACEUTICAL COMPOUNDS OF O-DESMETHYL-TRAMADOL AND COX-INHIBITORS<br/>[FR] COMPOSÉS PHARMACEUTIQUES COMPRENANT DE L'O-DESMÉTHYL-TRAMADOL ET DES INHIBITEURS COX
  申请人：ESTEVE LABOR DR

  公开号：WO2011015360A1

  公开（公告）日：2011-02-10

  The present invention relates to pharmaceutical compounds comprising O-desmethyl-Tramadol and at least one COX-inhibitor, especially NSAID, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain. The pharmaceutical compound may be a salt or a crystalline form of a salt or a co-crystal.

  本发明涉及包含O-去甲甲酚和至少一种COX-抑制剂，尤其是NSAID的药物化合物，以及其制备方法和作为药物或在制药配方中的用途，更具体地用于治疗疼痛。药物化合物可以是盐或盐的结晶形式或共晶体。
• Crystalline salts and/or co-crystals of O-desmethyltramadol
  申请人：GRUSS Michael

  公开号：US20110251286A1

  公开（公告）日：2011-10-13

  Salts and/or co-crystals of (+)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]-phenol or of (−)-3-[2-(dimethylamino)methyl-1-hydroxy-cyclohexyl]phenol, present in crystalline form, with cinnamic acid, C 8 - to C 10 -alkane-monocarboxylic acids, C 6 - to C 10 -alkanedicarboxylic acids, C 15 - to C 17 -alkane-monocarboxylic acids, fumaric acid, tartaric acid, mandelic acid, hippuric acid and/or embonic acid, a process for their production, and the use of such salts and/or co-crystals as medicaments.

  (+)-3-[2-(二甲氨基)甲基-1-羟基环己基]-苯酚或(−)-3-[2-(二甲氨基)甲基-1-羟基环己基]苯酚的盐和/或共晶，以结晶形式存在，与肉桂酸、C8-C10烷单羧酸、C6-C10烷二羧酸、C15-C17烷单羧酸、富马酸、酒石酸、苯甲酸和/或乙酰基苯甲酸，以及其制备方法和作为药物的使用。
• [EN] A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE D'O-DESMÉTHYLTRAMADOL ET DE SELS DE CELUI-CI
  申请人：R L FINE CHEM PRIVATE LTD

  公开号：WO2019053494A1

  公开（公告）日：2019-03-21

  The present invention relates to a process of preparation of O-Desmethyl tramadol through potassium hydroxide mediated demethylation of Tramadol under phase transfer conditions.

  本发明涉及一种通过钾氢氧化物介导的相转移条件下的曲马多去甲基化制备O-去甲基曲马多的方法。
• Composition comprising a tramadol material and any of codeine, oxycodone
  申请人：McNeil Lab, Inc.

  公开号：US05468744A1

  公开（公告）日：1995-11-21

  This invention relates to compositions comprising a tramadol material selected from the group consisting of tramadol, its stereoisomers and its pharmaceutically acceptable salts and either codeine or oxycodone, and their use in treating pain. When the components, i.e., tramadol materials and either of codeine or oxycodone, of the composition are within certain ratios of pharmacological effects of the compositions are superaddditive (synergistic).

  本发明涉及一种组合物，包括从由曲马多、其立体异构体和其药学上可接受的盐中选择的曲马多物质和可待因或氧可酮，以及它们在治疗疼痛中的用途。当组合物的组分，即曲马多物质和可待因或氧可酮中的任何一种，处于某些比例时，其药理效应是超加性（协同作用）。