[2-methoxy-4-(prop-2-en-1-yl)phenyl]oxidanesulfonic acid | 95480-60-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: [2-methoxy-4-(prop-2-en-1-yl)phenyl]oxidanesulfonic acid
• 英文别名: eugenol sulfate；sulfuric acid mono-(4-allyl-2-methoxy-phenyl ester)；Schwefelsaeure-mono-(4-allyl-2-methoxy-phenylester)；Eugenolschwefelsaeure；(2-methoxy-4-prop-2-enylphenyl) hydrogen sulfate
• CAS: 95480-60-7
• 化学式: C₁₀H₁₂O₅S
• 分子量: 244.268
• InChiKey: XWAZTQUZONPJEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  丁香酚 在 potassium pyrosulfate 、 N,N-二乙基苯胺 作用下， 生成 [2-methoxy-4-(prop-2-en-1-yl)phenyl]oxidanesulfonic acid
  参考文献：
  名称：

  Regional Accumulation of ¹⁴C-zonisamide in Rat Brain during Kainic Acid-induced Limbic Seizures

  摘要：

  背景：唑尼沙胺（ZNS）是日本开发的一种抗癫痫药物。各种实验研究都对 ZNS 的作用进行了调查。然而，ZNS对边缘型癫痫发作和继发性泛化的作用机制尚不清楚。方法：14 只雄性 Wistar 大鼠接受了立体定向手术。为了记录脑电图（EEG），电极被放置在左侧杏仁核（LA）、左侧海马背侧和左侧感觉运动皮层上。为了进行微量注射，还将不锈钢插管插入 LA。手术七天后，对大鼠进行麻醉，并将导管插入股静脉。将动物固定，让其从麻醉中恢复至少两小时。在 8 只大鼠的 LA 中注射 1.0μL （1.0μg）KA，在 6 只对照组大鼠的 LA 中注射 1.0μL 磷酸盐缓冲溶液。结果：在肢端状态癫痫期间，只有感觉运动皮层的癫痫发作在注射 14C-ZNS 几分钟后明显减弱。此外，在感觉运动皮层、顶叶皮层和丘脑（外侧部分）的同侧发现了对 14C-ZNS 的高摄取。结论：这些结果表明，ZNS 通过直接作用于大脑皮层来抑制肢体癫痫发作的继发性泛化。

  DOI：

  10.1017/s0317167100001554

文献信息

• 阿司匹林丁香酚酯两种代谢产物及其制备方法
  申请人：中国农业科学院兰州畜牧与兽药研究所

  公开号：CN108358981A

  公开（公告）日：2018-08-03

  本发明提供阿司匹林丁香酚酯两种代谢产物M1和M2，其化学结构式如下：M1通过丁香酚与氯磺酸反应，吡啶做缚碱剂和溶剂制得；M2通过丁香酚与2,3,4‑O‑三乙酰基‑β‑D‑葡萄糖醛酸甲酯三氯乙酰亚胺酯发生取代反应，然后在碱性条件下脱去乙酰基制得。阿司匹林丁香酚酯代谢产物M1和M2的制备方法合理，操作简便。
• Flavonoid compositions and methods of use
  申请人：Reoxcyn, LLC

  公开号：US10441621B2

  公开（公告）日：2019-10-15

  Flavonoid compositions containing the flavonoid quercetin and/or derivatives of quercetin are disclosed. The flavonoid compositions are formulated to improve the bioavailability of quercetin. Also provided herein are methods for improving athletic performance, improving cardiovascular health, and aiding in immune response and methods of improving athletic performance, improving bone health, preventing fatigue, reducing recovery time after exercise, countering oxidative stress, and/or boosting energy.

  本发明公开了含有类黄酮槲皮素和/或槲皮素衍生物的类黄酮组合物。黄酮组合物的配制可提高槲皮素的生物利用率。本文还提供了提高运动成绩、改善心血管健康和帮助免疫反应的方法，以及提高运动成绩、改善骨骼健康、防止疲劳、减少运动后恢复时间、对抗氧化应激和/或增强能量的方法。
• Verley, Bulletin de la Societe Chimique de France, 1901, vol. <3> 25, p. 49
  作者：Verley

  DOI：——

  日期：——
• FLAVONOID COMPOSITIONS AND METHODS OF USE
  申请人：Reoxcyn Discoveries Group, Inc.

  公开号：US20170106036A1

  公开（公告）日：2017-04-20

  Flavonoid compositions containing the flavonoid quercetin and/or derivatives of quercetin are disclosed. The flavonoid compositions are formulated to improve the bioavailability of quercetin. Also provided herein are methods for improving athletic performance, improving cardiovascular health, and aiding in immune response and methods of improving athletic performance, improving bone health, preventing fatigue, reducing recovery time after exercise, countering oxidative stress, and/or boosting energy.
• Regional Accumulation of ¹⁴C-zonisamide in Rat Brain during Kainic Acid-induced Limbic Seizures
  作者：Koichi Akaike、Shigeya Tanaka、Hideshi Tojo、Shin-ichiro Fukumoto、Morikuni Takigawa、Shin-ichi Imamura

  DOI：10.1017/s0317167100001554

  日期：2001.11

  Zonisamide (ZNS) is an antiepileptic drug developed in Japan. Various experimental studies have investigated the effects of ZNS. However, the mechanism of action of ZNS against limbic seizures and secondary generalization is not well-known. We studied ictal regional accumulation of ZNS in the rat brain during kainic acid (KA)-induced limbic status epilepticus.

  Fourteen male Wistar rats underwent a stereotactic operation. For recording the electroencephalogram (EEG), electrodes were placed in the left amygdala (LA), left dorsal hippocampus, and over the left sensorimotor cortex. For microinjection, a stainless steel cannula was also inserted into the LA. Seven days after surgery, rats were anesthetized and a catheter was inserted into the femoral vein. The animals were immobilized and allowed to recover from anesthesia for at least two hours. In eight rats, 1.0μL (1.0μg) of KA was injected into the LA, and 1.0 μL of phosphate buffer solution was injected into the LA in six control rats. Sixty minutes after injection, ¹⁴C-ZNS was administered intravenously, and an autoradiographic study was done.

  During limbic status epilepticus, only seizures in the sensorimotor cortex were markedly attenuated a few minutes after ¹⁴C-ZNS administration. Additionally, high uptake of ¹⁴C-ZNS was noted ipsilaterally in the sensorimotor cortex, parietal cortex and thalamus (lateral portion). In control rats, no EEG change was seen, and distribution of ¹⁴C-ZNS was rather homogeneous.

  These results suggested that ZNS suppresses secondary generalization of limbic seizures by a direct effect on the cerebral cortex.

  背景：唑尼沙胺（ZNS）是日本开发的一种抗癫痫药物。各种实验研究都对 ZNS 的作用进行了调查。然而，ZNS对边缘型癫痫发作和继发性泛化的作用机制尚不清楚。方法：14 只雄性 Wistar 大鼠接受了立体定向手术。为了记录脑电图（EEG），电极被放置在左侧杏仁核（LA）、左侧海马背侧和左侧感觉运动皮层上。为了进行微量注射，还将不锈钢插管插入 LA。手术七天后，对大鼠进行麻醉，并将导管插入股静脉。将动物固定，让其从麻醉中恢复至少两小时。在 8 只大鼠的 LA 中注射 1.0μL （1.0μg）KA，在 6 只对照组大鼠的 LA 中注射 1.0μL 磷酸盐缓冲溶液。结果：在肢端状态癫痫期间，只有感觉运动皮层的癫痫发作在注射 14C-ZNS 几分钟后明显减弱。此外，在感觉运动皮层、顶叶皮层和丘脑（外侧部分）的同侧发现了对 14C-ZNS 的高摄取。结论：这些结果表明，ZNS 通过直接作用于大脑皮层来抑制肢体癫痫发作的继发性泛化。