3-羟基丙基(三甲基)氯化铵 | 10238-59-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-羟基丙基(三甲基)氯化铵
• 英文名称: trimethylamino-1-propanol
• 英文别名: (3-Hydroxy-propyl)-trimethyl-ammonium；N,N,N-Trimethyl-3-hydroxypropyl-ammonium；3-Trimethylamino-1-propanol；3-Trimethylammonium-propanol-(1)；Trimethyl-(γ-oxy-propyl)-ammoniumhydroxyd；Trimethyl-(3-hydroxy-propyl)-ammonium；γ-Homocholin；Homocholine；3-hydroxypropyl(trimethyl)azanium
• CAS: 10238-59-2
• 化学式: C₆H₁₆NO
• 分子量: 118.199
• InChiKey: AACHVWXCVWWMSI-UHFFFAOYSA-N

物化性质

• 熔点：
  235-238 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-羟基丙基(三甲基)氯化铵 在 permanganate(VII) ion 作用下， 生成 (2-carboxy-ethyl)-trimethyl-ammonium; hydroxide
  参考文献：
  名称：

  Berlin, Zeitschrift fur Biologie (Munich), vol. 57, p. 30

  摘要：

  DOI：

文献信息

• Use of functionalized onium salts as a soluble support for organic synthesis
  申请人：Vaultier Michel

  公开号：US20070043234A1

  公开（公告）日：2007-02-22

  The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A 1 + , X 1 − , wherein A 1 + represents a cation and X 1 − represents an anion.

  该发明涉及使用至少一个有机功能官能化的离子盐作为可溶性支持体，在至少一个有机溶剂的存在下，用于在均相相中通过至少一个所述有机功能的转化对分子进行有机合成。该离子盐使合成的分子能够被释放。该离子盐在室温下以液态或固态形式存在，符合以下公式A1+，X1−，其中A1+代表阳离子，X1−代表阴离子。
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2017099823A1

  公开（公告）日：2017-06-15

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  这项披露提供了改进的基于脂质的组合物，包括脂质纳米粒子组合物，以及它们用于体内传递药剂的方法，包括核酸和蛋白质。这些组合物不受加速血清清除的影响，并且它们在体内具有改进的毒性特性。
• [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142474A1

  公开（公告）日：2020-07-09

  A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.

  提供了一种制备丙烯酸酯官能化分支有机硅化合物（“化合物”）的方法，包括在催化剂存在下，使（A）分支有机硅化合物和（B）丙烯酸酯化合物发生反应，其中组分（A）具有一般式X-Si（R1）3，其中X包括卤素官能基，每个R1从R和–OSi（R4）3中选择，但至少一个R1为–OSi（R4）3；每个R4从R、–OSi（R5）3和–[OSiR2]mOSiR3中选择；每个R5从R、–OSi（R6）3和–[OSiR2]mOSiR3中选择；每个R6从R和–[OSiR2]mOSiR3中选择；每个R是独立选择的烃基；且0≤m≤100；但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物，包括化合物和第二化合物的反应产物的共聚物，形成共聚物的方法，以及包含共聚物的组合物。
• COMPOSITION COMPRISING PRECURSOR FOR VOLATILES
  申请人：Henkel AG & Co. KGaA

  公开号：US20200224120A1

  公开（公告）日：2020-07-16

  A detergent, cleaning, fabric softener or cosmetic composition comprising a compound based on 1-Aza-3,7-dioxabicyclo[3.3.0]octane (bicyclic oxazolidine derivative) substituted with 3,7-dimethyl-1,6-nonyldien represented by formula (I) is disclosed.

  一种洗涤剂、清洁剂、织物柔软剂或化妆品组合物，包含基于1-Aza-3,7-dioxabicyclo[3.3.0]octane（双环氧杂环丁烷衍生物）的化合物，该化合物被3,7-二甲基-1,6-壬二烯取代，其代表性结构如式(I)所示。
• METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION
  申请人：Korea Advanced Institute of Science and Technology

  公开号：US20180066011A1

  公开（公告）日：2018-03-08

  A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a specific amino acid into a selected position of a target protein; (b) activation of the marked site; and (c) coupling of various post-translational modification (PTM) moieties or other chemical groups onto the activated site to obtain a site-specifically modified protein. The method for producing a site-specifically modified protein can incorporate desired diverse chemical groups including post-translational modification (PTM) moieties into a designated site in a target protein through a new carbon-carbon bond. Furthermore, the modified protein having a site-specific PTM exhibits the same chemical and functional properties as that of a target protein present in cells. Thus, the present invention is useful for studies of cellular proteins, human diseases including cancers and neurodegenerative diseases, and new drug discovery.

  揭示了一种基于新的碳-碳键形成的方法，用于产生具有特定位点修饰的蛋白质，包括以下三个步骤（标记、激活和偶联步骤）：(a) 通过将特定氨基酸纳入目标蛋白质的选定位置来标记修饰位点；(b) 激活标记的位点；以及(c) 将各种翻译后修饰（PTM）基团或其他化学基团偶联到激活位点，从而获得具有特定位点修饰的蛋白质。用于产生具有特定位点修饰的蛋白质的方法可以通过新的碳-碳键将所需的多样化化学基团，包括翻译后修饰（PTM）基团，纳入目标蛋白质的指定位点。此外，具有特定位点PTM的修饰蛋白质表现出与细胞中存在的目标蛋白质相同的化学和功能特性。因此，本发明对于细胞蛋白质、包括癌症和神经退行性疾病在内的人类疾病的研究以及新药物发现是有用的。