4-Hydroxy-2-phenyl-butanon-(1) | 22927-18-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroxy-2-phenyl-butanon-(1)
• 英文别名: 2-Phenyl-4-hydroxy-butyraldehyd；4-Hydroxy-2-phenylbutanal；4-hydroxy-2-phenylbutanal
• CAS: 22927-18-0
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.204
• InChiKey: LTRKNIBHEGXNIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-2-phenyl-butanon-(1) 在 sodium tetrahydroborate 作用下， 生成 (+/-)-2-phenyl-1,4-butanediol
  参考文献：
  名称：

  Synthesis of 1-substituted (S)-4-acetoxy-1-penten-3-ones using (S)-lactic acid as a chiral source and their synthetic reactions

  摘要：

  DOI：

  10.1016/s0040-4039(01)91269-9
• 作为产物：
  描述：

  (E)-(3S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-hept-4-enoic acid ethyl ester 在 臭氧 作用下， 生成 4-Hydroxy-2-phenyl-butanon-(1)
  参考文献：
  名称：

  Synthesis of 1-substituted (S)-4-acetoxy-1-penten-3-ones using (S)-lactic acid as a chiral source and their synthetic reactions

  摘要：

  DOI：

  10.1016/s0040-4039(01)91269-9

文献信息

• Regioselective Hydroformylation of Allylic Alcohols
  作者：Thomas E. Lightburn、Omar A. De Paolis、Ka H. Cheng、Kian L. Tan

  DOI：10.1021/ol200782d

  日期：2011.5.20

  hydroformylation of allylic alcohols is reported toward the synthesis of β-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur. The application to trisubstituted olefins was also demonstrated, which yields a single diastereomer product consistent with a stereospecific addition of CO

  据报道，烯丙醇的高度区域选择性加氢甲酰化可用于合成 β-羟基酸和醛产物。选择性是通过使用一种配体来实现的，该配体在原位可逆地结合醇，允许发生定向加氢甲酰化。还证明了三取代烯烃的应用，这产生了与 CO 和氢的立体有择加成一致的单一非对映异构体产品。
• Synthesis of aldehydes from dihydro-1,3-oxazines
  作者：A. I. Meyers、A. Nabeya、H. W. Adickes、I. R. Politzer、G. R. Malone、A. C. Kovelesky、R. L. Nolen、R. C. Portnoy

  DOI：10.1021/jo00941a008

  日期：1973.1
• Aldehydes from dihydro-1,3-oxazines. IV. Synthesis of .gamma.-hydroxy aldehydes and their .gamma.-oxo derivatives
  作者：H. Wayne Adickes、Ieva R. Politzer、Albert I. Meyers

  DOI：10.1021/ja01036a076

  日期：1969.4
• INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：ELI LILLY AND COMPANY

  公开号：EP2021337B1

  公开（公告）日：2010-01-13
• Synthesis of 1-substituted (S)-4-acetoxy-1-penten-3-ones using (S)-lactic acid as a chiral source and their synthetic reactions
  作者：Tamejiro Hiyama、Kumi Kobayashi、Makoto Fujita

  DOI：10.1016/s0040-4039(01)91269-9

  日期：1984.1