2'-(4-fluorophenyl)-21-iodo-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole | 540475-59-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2'-(4-fluorophenyl)-21-iodo-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole
• 英文别名: 1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-iodoethanone
• CAS: 540475-59-0
• 化学式: C₂₈H₃₂FIN₂O₃
• 分子量: 590.477
• InChiKey: KZVFGQNZHDPLQZ-LQHZEQFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2'-(4-fluorophenyl)-21-iodo-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole 在 potassium [¹⁸F]fluoride 作用下， 以 乙腈 为溶剂， 反应 0.33h， 以80%的产率得到2'-(4-fluorophenyl)-21-[18F]fuoro-20-oxo-11β,17α-dihydroxy-pregn-4-ene[3,2-c]pyrazole
  参考文献：
  名称：

  Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors

  摘要：

  Corticosteroids regulate a variety of essential physiological functions, such as mineral balance and stress. The great interest in these steroids, especially the glucocorticoids, stems from roles they are thought to play in neuropsychiatric disorders, such as severe depression and anxiety.The development of glucocorticoid receptor (GR) ligands which are appropriately labeled with short-lived positron-emitting radioisotopes would allow the non-invasive in-vivo imaging and mapping of brain GRs by means of positron emission tomography (PET). In this context we have synthesized a series of novel arylpyrazolo steroids exhibiting different substitution patterns at the D-ring of the steroid skeleton, as ligands for brain GRs. Special attention was given to 4-fluorophenyl pyrazolo steroids, which are known to display high binding affinity toward the GR. The compounds were evaluated in a competitive radiometric receptor binding assay to determine their relative binding affinities (RBA) to the GR. Some compounds show good binding affinities of up to 56% in comparison to dexamethasone (100%). In initial experiments, selected candidates were labeled with the positron emitter fluorine-18 and in one case with the gamma-emitter iodine-131. (C) 2002 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(02)00171-x
• 作为产物：
  描述：

  2'(4-fluorophenyl)-11β,17α,21-trihydroxy-20-oxo-pregn-4-eno[3,2-c]pyrazole 在 吡啶 、 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 3.0h， 生成 2'-(4-fluorophenyl)-21-iodo-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole
  参考文献：
  名称：

  Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors

  摘要：

  Corticosteroids regulate a variety of essential physiological functions, such as mineral balance and stress. The great interest in these steroids, especially the glucocorticoids, stems from roles they are thought to play in neuropsychiatric disorders, such as severe depression and anxiety.The development of glucocorticoid receptor (GR) ligands which are appropriately labeled with short-lived positron-emitting radioisotopes would allow the non-invasive in-vivo imaging and mapping of brain GRs by means of positron emission tomography (PET). In this context we have synthesized a series of novel arylpyrazolo steroids exhibiting different substitution patterns at the D-ring of the steroid skeleton, as ligands for brain GRs. Special attention was given to 4-fluorophenyl pyrazolo steroids, which are known to display high binding affinity toward the GR. The compounds were evaluated in a competitive radiometric receptor binding assay to determine their relative binding affinities (RBA) to the GR. Some compounds show good binding affinities of up to 56% in comparison to dexamethasone (100%). In initial experiments, selected candidates were labeled with the positron emitter fluorine-18 and in one case with the gamma-emitter iodine-131. (C) 2002 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(02)00171-x

文献信息

• Wuest, F.; Kniess, T.; Bergmann, R., Journal of labelled compounds and radiopharmaceuticals, 2003, vol. 46, p. S142 - S142
  作者：Wuest, F.、Kniess, T.、Bergmann, R.

  DOI：——

  日期：——
• Synthesis and radiopharmacological evaluation of 2′-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET)
  作者：Frank Wüst、Torsten Kniess、Marion Kretzschmar、Ralf Bergmann

  DOI：10.1016/j.bmcl.2005.01.033

  日期：2005.3

  The radiosynthesis and the radiopharmacological evaluation of pyrazolo steroid 2'-(4-fluorophenyl)-21-[F-18]fluoro-20-oxo-1 11 beta, 17 alpha-dihydroxy-pregn-4-eno[3,2-c]pyrazole [F-18]-2 is described. The radiolabeling was accomplished in 3-4% decay-corrected radiochemical yield within 80 min at an specific radioactivity of 0.8-1.2 Ci/mu mol. Biodistribution studies in male Wistar rats showed an initial brain uptake of 0.25 +/- 0.03% ID/g after 5 min, which remained constant over 60 min. The radiopharmacological evaluation of compound [F-18]-2 was completed with autoradiography using rat brain sections and micro-PET imaging. (c) 2005 Elsevier Ltd. All rights reserved.