butyl(2-hydroxyethyl)dimethylammonium hydroxide | 114380-13-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: butyl(2-hydroxyethyl)dimethylammonium hydroxide
• 英文别名: Butyl-(2-hydroxyethyl)-dimethylazanium;hydroxide
• CAS: 114380-13-1
• 化学式: C₈H₂₀NO*HO
• 分子量: 163.26
• InChiKey: NSLABOVQLYGVPA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.68
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-丁基磷酸 、 butyl(2-hydroxyethyl)dimethylammonium hydroxide 以 水 、 丙酮 为溶剂， 生成
  参考文献：
  名称：

  Improvement of New Dianionic Ionic Liquids vs Monoanionic in Solubility of Poorly Water-Soluble Drugs

  摘要：

  DOI：

  10.1016/j.xphs.2021.01.014
• 作为产物：
  描述：

  dimethylbutyl(β-hydroxyethyl)ammonium chloride 在 anion exchange resin 作用下， 生成 butyl(2-hydroxyethyl)dimethylammonium hydroxide
  参考文献：
  名称：

  Dual functions of N,N-dimethylethanolamnium-based ionic liquids for the Knoevenagel reactions at room temperature

  摘要：

  In this work, the hydrogen bond formation ability of cation and anion of the ILs was determined by using the solvatochromic method and was found to be responsible for their catalytic activity in the Knoevenagel reactions. The enhancement in the hydrogen bond donor ability of the cations and the hydrogen bond acceptor ability of the anions can both lead to the increase in the catalytic activity of the ILs. From the proposed reaction mechanism, it was deduced that the cations of the ILs can form hydrogen bond with aldehyde to activate the C=O bond as electrophile, and the anions of the ILs can promote active methylene compound to produce carboanion as nucleophile, showing dual function activation effect in the catalytic processes. In addition, the optimized N,N-dimethylethanolamnium acetate as dual function activator for the Koevenagel reactions benefits from wide substrates tolerance, ambient reaction temperature, easy work-up procedure, and easy reuse of the IL. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cattod.2012.06.006

文献信息

• Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids
  作者：Ana R. Jesus、Mário R.C. Soromenho、Luís R. Raposo、José M.S.S. Esperança、Pedro V. Baptista、Alexandra R. Fernandes、Patrícia M. Reis

  DOI：10.1016/j.ejpb.2019.03.004

  日期：2019.4

  potential solvents for poorly water-soluble drug molecules. Ionic liquids (ILs) have attracted this industry as (co-) solvents due to their unique physicochemical and biological properties. Herein, a straightforward approach for the enhancement of the water solubility of paracetamol and sodium diclofenac is presented, using new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids as

  制药行业的主要挑战是寻找水溶性差的药物分子的潜在溶剂。离子液体（IL）由于其独特的物理化学和生物学特性，已作为（共）溶剂吸引了该行业。在此，提出了一种使用新的生物相容性N-乙酰基氨基酸N来增强对乙酰氨基酚和双氯芬酸钠的水溶性的直接方法。-烷基胆碱基离子液体作为助溶剂（0.2-1摩尔％）。这些新的离子液体能够将这些药物的水溶性提高到纯水或无机盐溶液中的四倍。在存在这些IL的情况下，药物的亲脂性（对乙酰氨基酚的log P没有显着变化，但对双氯芬酸钠而言，其亲脂性有可能显着降低。关于人皮肤成纤维细胞的细胞毒性，观察到IL并未显示出明显的毒性）。与各自的前体相比，能够提高细胞活力。
• Convenient and Efficient Method for the Synthesis of Phthalocyanines and Metallophthalocyanines in Task-Specific 2-Hydroxyethyl Ionic Liquids
  作者：Kumar Karitkey Yadav、Poonam、Shive M. S. Chauhan

  DOI：10.1080/00397911.2013.867505

  日期：2014.10.2

  ammonium ionic liquids at 100 °C gave corresponding phthalocyanines in moderate yield. Further the reaction of substituted phthalonitriles in the presence of transition-metal salts in ionic liquids gave the corresponding metallophthalocyanines. The 2-hydroxylethyl ammonium ionic liquids gave better yields of phthalocyanines than 2-hydroxylethyl imidazolium and nonhydroxyl functionalized ionic liquids. The

  摘要 在任务特定的 2-羟乙基基咪唑鎓和铵离子液体中，取代的邻苯二甲腈在 100 °C 下四聚化，以中等产率得到相应的酞菁。此外，在过渡金属盐的存在下，取代的邻苯二甲腈在离子液体中的反应得到相应的金属酞菁。2-羟乙基铵离子液体比2-羟乙基咪唑鎓和非羟基官能化离子液体产生更好的酞菁收率。不同酞菁的分离和分离采用硅胶柱色谱法完成，产物采用多种光谱技术进行表征。图形概要