procainium hydrocarbonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: procainium hydrocarbonate
• 英文别名: Procaine Carbonic Acid；carbonic acid;2-(diethylamino)ethyl 4-aminobenzoate
• 化学式: CH₂O₃*C₁₃H₂₀N₂O₂
• 分子量: 298.339
• InChiKey: PVCQJVLZCAQDJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.76
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  procainium hydrocarbonate 生成 普鲁卡因
  参考文献：
  名称：

  [DE] AMMONIUMSALZE UND AMMONIUMSALZ-MINERALSALZCLATHRATE ALS TRANSPORT- UND WIRKFORM FÜR PHARMAZEUTISCH-MEDIZINISCHE UND ALS PHASENTRANSFERMIITEL FÜR CHEMISCHE ANWENDUNGEN
  [EN] AMMONIUM SALTS AND AMMONIUM SALT/MINERAL SALT CLATHRATE COMPOUNDS FOR USE AS VEHICLE AND EFFECTIVE FORM FOR PHARMACO-MEDICAL APPLICATIONS AND FOR USE AS PHASE TRANSFER AGENTS FOR CHEMICAL APPLICATIONS
  [FR] SELS D'AMMONIUM ET CLATHRATES DE SELS D'AMMONIUM ET DE SELS MINERAUX CONSTITUANT UNE FORME DE TRANSPORT ET UNE FORME ACTIVE POUR DES APPLICATIONS MEDICO-PHARMACEUTIQUES ET DES AGENTS DE TRANSFERT DE PHASE POUR DES APPLICATIONS CHIMIQUES

  摘要：

  公开号：

  WO2006007835A3
• 作为产物：
  描述：

  普鲁卡因 在 水 作用下， 生成 procainium hydrocarbonate
  参考文献：
  名称：

  [DE] AMMONIUMSALZE UND AMMONIUMSALZ-MINERALSALZCLATHRATE ALS TRANSPORT- UND WIRKFORM FÜR PHARMAZEUTISCH-MEDIZINISCHE UND ALS PHASENTRANSFERMIITEL FÜR CHEMISCHE ANWENDUNGEN
  [EN] AMMONIUM SALTS AND AMMONIUM SALT/MINERAL SALT CLATHRATE COMPOUNDS FOR USE AS VEHICLE AND EFFECTIVE FORM FOR PHARMACO-MEDICAL APPLICATIONS AND FOR USE AS PHASE TRANSFER AGENTS FOR CHEMICAL APPLICATIONS
  [FR] SELS D'AMMONIUM ET CLATHRATES DE SELS D'AMMONIUM ET DE SELS MINERAUX CONSTITUANT UNE FORME DE TRANSPORT ET UNE FORME ACTIVE POUR DES APPLICATIONS MEDICO-PHARMACEUTIQUES ET DES AGENTS DE TRANSFERT DE PHASE POUR DES APPLICATIONS CHIMIQUES

  摘要：

  公开号：

  WO2006007835A3

文献信息

• Ammonium Salts and Ammonium Salt/Mineral Salt Clathrate Compounds for Use as Vehicle and Effective Form for Pharmaco-Medical Applications and for Use as Phase Transfer Agents for Chemical Applications
  申请人：Kasch Helmut

  公开号：US20080317729A1

  公开（公告）日：2008-12-25

  This invention relates to ammonium salts and stable storable ammonium salts and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues such as bicarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds. According to the invention, compounds for pharmaco-medical and chemical synthetic applications are produced which comprise the ammonium salt and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues of general formula I with R1, R2, R3 and R4=alkyl and substituted alkyl straight-chain or branched, optionally having an alcohol, ether, silyether, ester, amino or amide function, H or aryl-alkyl, with aryl being an aromatic or heteroaromatic ring having optionally additional substituents, such as alkyl having 1 to 4 C atoms, OH, NR* 2 with R* 2 =O, alkyl with alkyl of between 1 and 4 C atoms or H, COOH, COOR, CN, NO 2 and the cationic positive N + is optionally part of an active agent, Y is a dibasic acid residue of an organic dicarboxylic acid or CO 3 − , corresponding to HY − =HCO 3 − , and x=0.5 to 30 represents the number of the mineral salt molecules for clathrate compound formation or 0. In pharmaco-medical applications applies the generalizable effectiveness principle according to which to ammonium salt/mineral salt cluster is used as vehicle and active agent for novel forms of application of nitrogen-containing active agent bases. In chemistry, these agents are used in the synthesis of active agents and valuable products, e.g. of cyclic carbonates.

  本发明涉及铵盐和稳定的可储存铵盐以及含有酸二元阴离子酸残基（如碳酸氢根）的铵盐/矿物盐包合物（包括化合物、团簇），以及它们的制备方法和药理医学和化学合成应用。根据本发明，制备了用于药理医学和化学合成应用的化合物，其中包括具有通式I的铵盐和铵盐/矿物盐包合物（包括化合物、团簇），其具有酸二元阴离子酸残基，其中R1、R2、R3和R4=直链或支链的烷基和取代烷基，可选择具有醇、醚、硅醚、酯、氨基或酰胺功能，H或芳基-烷基，其中芳基是具有可选择的额外取代基团（如1到4个碳原子的烷基、OH、NR*2，其中R*2=O、1到4个碳原子的烷基或H、COOH、COOR、CN、NO2）的芳香或杂环芳香环，阳离子正电荷N+可选择是活性剂的一部分，Y是有机二羧酸或CO3−的二元酸残基，相应地HY−=H −，x=0.5到30表示包合物形成的矿物盐分子数或0。在药理医学应用中，适用于可推广有效性原则，根据该原则，铵盐/矿物盐团簇被用作氮含活性剂碱新型应用的载体和活性剂。在化学中，这些剂被用于活性剂和有价值的产品的合成，例如环状碳酸酯。
• AMMONIUMSALZE UND AMMONIUMSALZ-MINERALSALZCLATHRATE ALS TRANSPORT- UND WIRKFORM FÜR PHARMAZEUTISCH-MEDIZINISCHE UND ALS PHASENTRANSFERMITTEL FÜR CHEMISCHE ANWENDUNGEN
  申请人：Kasch, Helmut

  公开号：EP1776333B1

  公开（公告）日：2011-01-12
• KOHLENSÄURE-ADDUKTE
  申请人：inflamed pharma GmbH

  公开号：EP3679010B1

  公开（公告）日：2021-10-27
• CARBONIC ACID ADDUCTS
  申请人：JENCLUSTER GMBH

  公开号：US20200216384A1

  公开（公告）日：2020-07-09

  The present invention relates to a carbonic acid adduct (CAA) comprising carbonic acid, at least one amine, and optionally at least one salt, said adduct being producible by a method comprising the following steps: a) providing a solution (A) comprising dissolved CO 2 ; optionally b) dissolving a base (BA) not corresponding to the amine (AM) in the solution (A) so as to obtain the solution (A1); c) dissolving the at least one amine (AM) in the solution (A) or (A1) so as to obtain the solution (B); d) freezing the solution obtained after completion of step c); and e) storing the solution frozen in step d) at −100 to 0° C. for no longer than 4 days. The content of CO 2 in the solution that is subjected to step c) is at least 6 g/l. The invention also relates to a method for producing the carbonic acid adduct (CAA), a pharmaceutical preparation (PP) comprising the carbonic acid adduct (CAA), and methods for the production thereof and use of the carbonic acid adduct (CAA) or the pharmaceutical preparation (PP) in therapy for a range of indications.
• US4097665A
  申请人：——

  公开号：US4097665A

  公开（公告）日：1978-06-27