N-环戊基-N，N-二甲基-3,4-双（十四烷基氧基）-苯甲铵碘化物 | 1202208-36-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-环戊基-N，N-二甲基-3,4-双（十四烷基氧基）-苯甲铵碘化物
• 英文名称: N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide
• 英文别名: cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium;iodide
• CAS: 1202208-36-3
• 化学式: C42H78INO2
• 分子量: 756.0
• InChiKey: UXOPVNPWTUWUEA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  10.37
• 重原子数：
  46
• 可旋转键数：
  31
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Gastrointestinal tract detection methods, devices and systems
  申请人：Progenity Inc.

  公开号：US10610104B2

  公开（公告）日：2020-04-07

  The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

  本公开涉及胃肠道（GI）检测方法、装置和系统。
• Treating hyperammonemia, reducing plasma ammonia with TLR4 antagonists
  申请人：YAQRIT LIMITED

  公开号：US10639346B2

  公开（公告）日：2020-05-05

  The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.

  本发明源于以下发现：Toll样受体4（TLR4）水平的升高与肝功能衰竭、肾功能障碍和/或脑部功能障碍有关，而通过降低体内TLR4水平，可减少因叠加感染或炎症而诱发肝病的肾脏和脑部后果。因此，本发明提供了TLR4拮抗剂，用于治疗伴有肾或脑功能障碍的肝病患者。
• Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
  申请人：Progenity, Inc.

  公开号：US11007356B2

  公开（公告）日：2021-05-18

  An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

  一种可摄取装置，包括一个用于储存可分配物质的储存器和一个加压室，当从加压室移除限制力时，可分配物质通过可摄取装置上的开口排出可摄取装置。
• Ingestible device and associated methods
  申请人：Progenity Inc.

  公开号：US11224364B2

  公开（公告）日：2022-01-18

  An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.

  本研究公开了一种可摄取的装置，它可以产生一种或多种分析物的光谱数据，还公开了相关方法，用于描述含有这些分析物的受试者的胃肠道特征。还公开了相关的试剂盒和系统。
• TREATMENT
  申请人：Jalan, Rajiv

  公开号：EP2605763A1

  公开（公告）日：2013-06-26