N-环戊基-n-丙胺 | 39190-95-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-环戊基-n-丙胺
• 英文名称: N-propylcyclopentylamine
• 英文别名: N-propylcyclopentanamine
• CAS: 39190-95-9
• 化学式: C₈H₁₇N
• mdl: MFCD08691712
• 分子量: 127.23
• InChiKey: OPZNSPHUHIXVGR-UHFFFAOYSA-N

物化性质

• 沸点：
  168.9±8.0 °C(Predicted)
• 密度：
  0.84±0.1 g/cm3(Predicted)
• 保留指数：
  982

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  N-环戊基-n-丙胺 在 乙醇 、 水 、 sodium 、 sodium hydrogensulfite 、 苯酚 作用下， 生成 N'-(6-chloro-2-methoxy-acridin-9-yl)-N-cyclopentyl-N-propyl-ethylenediamine
  参考文献：
  名称：

  2-甲氧基-6-氯-9-（N-取代的氨基）-啶; 衍生自环状仲胺的化合物。

  摘要：

  DOI：

  10.1021/ja01214a012
• 作为产物：
  描述：

  环戊酮肟 在 二异丁基氢化铝 作用下， 以 吡啶 为溶剂， 反应 1.08h， 生成 N-环戊基-n-丙胺
  参考文献：
  名称：

  Organoaluminum-promoted Beckmann rearrangement of oxime sulfonates

  摘要：

  DOI：

  10.1021/ja00347a052

文献信息

• [EN] HERBICIDAL PYRIDAZINONES<br/>[FR] PYRIDAZINONES HERBICIDES
  申请人：DU PONT

  公开号：WO2014031971A1

  公开（公告）日：2014-02-27

  Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, INSERT FORMULA 1 HERE wherein A is a radical selected from the group consisting of INSERT FORMULA A-1, A-2, A-3, A-4, A-5, A-6 AND A-7 HERE and B1, B2, B3, T, R1, R2, R3, R3A, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

  披露了公式1的化合物，包括所有立体异构体、N-氧化物和盐，INSERT FORMULA 1 HERE 其中A是选择自以下组的自由基：INSERT FORMULA A-1, A-2, A-3, A-4, A-5, A-6 AND A-7 HERE，B1, B2, B3, T, R1, R2, R3, R3A, R4, R5, R6, R7, R8, R9, R10, R11, R12和R13如披露中定义。还披露了包含公式1化合物的组合物，以及控制不需要的植被的方法，包括将不需要的植被或其环境与有效量的化合物或本发明的组合物接触。
• [EN] 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS<br/>[FR] DÉRIVÉS DE PIPÉRIDINE OU PIPÉRAZINE SUBSTITUÉS PAR 1,2,4-OXADIAZOLE COMME ANTAGONISTES DE SMO
  申请人：ANGELETTI P IST RICHERCHE BIO

  公开号：WO2010013037A1

  公开（公告）日：2010-02-04

  The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

  本发明涉及式(I)的化合物及其药学上可接受的盐、立体异构体或互变异构体，这些化合物是Sonic Hedgehog途径的抑制剂，特别是Smo拮抗剂。因此，本发明的化合物对治疗与异常Hedgehog途径激活相关的疾病有用，包括癌症，例如基底细胞癌、髓母细胞瘤、前列腺、胰腺、乳腺、结肠、骨骼和小细胞肺癌，以及上消化道的癌症。
• [EN] HERBICIDAL PYRAZINONES<br/>[FR] PYRAZINONES HERBICIDES
  申请人：DU PONT

  公开号：WO2012148622A1

  公开（公告）日：2012-11-01

  Disclosed are compounds of Formula (1), including all stereoisomers, N oxides, and salts thereof, wherein A is a radical selected from the group consisting of and B1, B2, B3, T, R1, R2 R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention. Also disclosed are compounds useful as intermediates for preparing compounds of Formula (1).

  揭示了Formula（1）的化合物，包括所有立体异构体、N-氧化物和盐，其中A是从B1、B2、B3、T、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13和R14组成的基团之一，如所述所定义。还揭示了含有Formula 1的化合物的组合物，以及用于控制不良植被的方法，包括将不良植被或其环境与本发明的化合物或组合物的有效量接触。还揭示了作为制备Formula（1）化合物的中间体有用的化合物。
• [EN] NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY<br/>[FR] NOUVEAUX IMIDAZOLES AMINES EN TANT QUE MODULATEURS D'ACTIVITÉ KINASE
  申请人：MERCK PATENT GMBH

  公开号：WO2013040059A1

  公开（公告）日：2013-03-21

  The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  该发明提供了根据式（I）和式（II）的新型咪唑胺化合物，其制备和用于治疗高增殖性疾病，如癌症。
• [EN] PREPARATION AND USE OF 2-SUBSTITUTED-5-OXO-3- PYRAZOLIDINECARBOXYLATES<br/>[FR] PREPARATION ET UTILISATION DE PYRAZOLIDINECARBOXYLATES-5-OXO-3-SUBSTITUES-2
  申请人：DU PONT

  公开号：WO2004087689A1

  公开（公告）日：2004-10-14

  A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I. The method comprises contacting a succinic acid derivative of the formula R1OC(O)C(H)(X)C(R2a)(R2b)C(O)Y (i.e. Formula II) wherein X and Y are leaving groups and L, R1, R2a and R2bare as defined in the disclosure, with a substituted hydrazine of the formula LNHNH2 (i.e. Formula III) in the presence of a suitable acid scavenger and solvent. Also disclosed is the preparation of compounds of Formula IV wherein X1, R6, R7, R8a, R8b, R9, and n are as defined in the disclosure. Also disclosed is a composition comprising on a weight basis about 20 to 99% of the compound of Formula II wherein R1, R2a, R2b, R3, R4 and R5 are as defined in the disclosure; X is Cl, Br or I; and Y is F, Cl, Br or I; provided that when R2a and R2b are each H, and X and Y are each Cl then R1 is other than benzyl and when R2a and R2b are each phenyl, and X and Y are each Cl, then R1 is other than methyl or ethyl. Also disclosed is a crystalline composition comprising at least about 90% by weight of the compound of the formula R1OC(O)C(H)(X)C(R2a)(R2b)CO2H (i.e. Formula VI) wherein R2a and R2b are H, X is Br and R1 is methyl.

  揭示了一种制备化合物的方法，该化合物为公式I中的2-取代-5-氧代-3-吡唑烷羧酸酯。该方法包括将公式为R1OC(O)C(H)(X)C(R2a)(R2b)C(O)Y（即公式II）的琥珀酸衍生物与适当的酸中和剂和溶剂存在下，与公式为LNHNH2（即公式III）的取代肼接触。还揭示了制备公式IV中的化合物，其中X1、R6、R7、R8a、R8b、R9和n如披露中所定义。还揭示了一种组合物，按重量基准含有约20至99%的公式II中的化合物，其中R1、R2a、R2b、R3、R4和R5如披露中所定义；X为Cl、Br或I；Y为F、Cl、Br或I；但当R2a和R2b分别为H，X和Y分别为Cl时，则R1不是苄基；当R2a和R2b分别为苯基，X和Y分别为Cl时，则R1不是甲基或乙基。还揭示了一种晶体组合物，其至少按重量含有约90%的公式为R1OC(O)C(H)(X)C(R2a)(R2b)CO2H（即公式VI）的化合物，其中R2a和R2b为H，X为Br，R1为甲基。