N-甲基-1-(苯甲基)-3-氮杂环丁胺 | 223381-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-甲基-1-(苯甲基)-3-氮杂环丁胺
• 英文名称: 1-Benzyl-N-methylazetidin-3-amine
• CAS: 223381-60-0
• 化学式: C₁₁H₁₆N₂
• mdl: MFCD11617819
• 分子量: 176.26
• InChiKey: YQKXKQBIHONSOW-UHFFFAOYSA-N

物化性质

• 沸点：
  253℃
• 密度：
  1.04
• 闪点：
  100℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS ANTAGONISTES DU RÉCEPTEUR DE TYPE TOLL ET LEURS MÉTHODES D'UTILISATION
  申请人：DYNAVAX TECH CORP

  公开号：WO2018089695A1

  公开（公告）日：2018-05-17

  The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

  该发明涉及以下式（I）的化合物：或其盐或溶剂化合物，其中变量如本文所述。式（I）的化合物及其药物组合物是Toll样受体拮抗剂，如TLR7、TLR8和/或TLR9，可用于抑制免疫反应并治疗与不良免疫反应相关的疾病。
• Toll-like receptor antagonist compounds and methods of use
  申请人：Dynavax Technologies Corporation

  公开号：US11370794B2

  公开（公告）日：2022-06-28

  The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I), and pharmaceutical compositions thereof, are antagonists of toll-like receptors such as TLR7, TLR8, and/or TLR9. In certain embodiments, compounds of the invention are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

  本发明涉及式 (I) 化合物： 或其盐或溶液，其中变量如本文所述。式（I）化合物及其药物组合物是类毒素受体如 TLR7、TLR8 和/或 TLR9 的拮抗剂。在某些实施方案中，本发明的化合物可用于抑制免疫反应和治疗与不良免疫反应相关的疾病。
• TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE
  申请人：Dynavax Technologies Corporation

  公开号：US20190345161A1

  公开（公告）日：2019-11-14

  The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.
• [EN] SYNTHESIS OF AZETIDINE DERIVATIVES<br/>[FR] SYNTHESE DE DERIVES D'AZETIDINE
  申请人：——

  公开号：WO1999019297A1

  公开（公告）日：1999-04-22

  [EN] The present invention provides compound having formula (I) useful as building blocks for combinatorial libraries and methods of making such compounds. Also provided are compositions comprising the compounds.
  [FR] La présente invention concerne un composé de la formule (I) utile sous la forme de blocs de construction pour des banques combinatoires ainsi que des méthodes de production de ces composés. L'invention concerne également des compositions comprenant les composés.