1-Methyl-3-piperidinecarboxylic acid benzyl ester | 3309-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methyl-3-piperidinecarboxylic acid benzyl ester
• 英文别名: benzyl 1-methylpiperidine-3-carboxylate
• CAS: 3309-23-7
• 化学式: C₁₄H₁₉NO₂
• 分子量: 233.31
• InChiKey: GKNNRYJKHVPYCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ARYL-PIPERIDINE DERIVATIVES
  申请人：Artax Biopharma Inc.

  公开号：US20200131125A1

  公开（公告）日：2020-04-30

  An aryl-piperidine derivative of formula I, wherein the meaning of R 3 , X, Cz, and Cy is that specified in the description, for use as inhibitors of T cells.
• US7745441B1
  申请人：——

  公开号：US7745441B1

  公开（公告）日：2010-06-29
• [EN] SUBSTITUTED PYRAZOLE DERIVATIVES AS SELECTIVE CDK12/13 INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS SÉLECTIFS DE CDK12/13
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2019193509A1

  公开（公告）日：2019-10-10

  The present invention provides substituted pyrazole derivatives of formula (I), which are therapeutically useful as selective CDK12/13 inhibitors. These compounds are useful in the treatment and/or prevention of diseases and/or disorders associated with CDK12/13 in a mammal. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the substituted pyrazole derivatives of formula (I) or a pharmaceutically acceptable salt, a N-oxide or a stereoisomer thereof.