(S)-3-(2-ethylphenyl)cyclohexanone | 1309435-09-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-3-(2-ethylphenyl)cyclohexanone
• 英文别名: (3S)-3-(2-ethylphenyl)cyclohexan-1-one
• CAS: 1309435-09-3
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: TXCHXJADCTYERM-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-环己烯-1-酮 、 2-乙基苯硼酸 在 C₄₂H₄₆O₆Rh₂S₂ 、 cesium fluoride 作用下， 以 1,4-二氧六环 为溶剂， 以99%的产率得到(S)-3-(2-ethylphenyl)cyclohexanone
  参考文献：
  名称：

  Sulfoxide–Alkene Hybrids: A New Class of Chiral Ligands for the Hayashi–Miyaura Reaction

  摘要：

  Sulfoxide-alkene hybrids are introduced as a new class of chiral heterodentate ligands for the Hayashi-Miyaura reaction. The synthesis of these ligands was achieved without the use of protecting groups. A chiral resolution was performed via simple column-chromatographic separation of the diastereomeric ligands. Both diastereomers proved to be excellent ligands In Rh-catalyzed 1,4-addition reactions, furnishing chiral Products with high enantloselectivities and, remarkably, opposite stereoconfigurations.

  DOI：

  10.1021/ol200841x

文献信息

• Sulfoxide–Alkene Hybrids: A New Class of Chiral Ligands for the Hayashi–Miyaura Reaction
  作者：Tobias Thaler、Li-Na Guo、Andreas K. Steib、Mihai Raducan、Konstantin Karaghiosoff、Peter Mayer、Paul Knochel

  DOI：10.1021/ol200841x

  日期：2011.6.17

  Sulfoxide-alkene hybrids are introduced as a new class of chiral heterodentate ligands for the Hayashi-Miyaura reaction. The synthesis of these ligands was achieved without the use of protecting groups. A chiral resolution was performed via simple column-chromatographic separation of the diastereomeric ligands. Both diastereomers proved to be excellent ligands In Rh-catalyzed 1,4-addition reactions, furnishing chiral Products with high enantloselectivities and, remarkably, opposite stereoconfigurations.