8-decahydronaphthalen-2-yl-4-phenyl-1,4,8-triazaspiro[4.5]decan-2-one | 494769-85-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 8-decahydronaphthalen-2-yl-4-phenyl-1,4,8-triazaspiro[4.5]decan-2-one
• 英文别名: 8-(1,2,3,4,4a,5,6,7,8,8a-Decahydronaphthalen-2-yl)-4-phenyl-1,4,8-triazaspiro[4.5]decan-2-one
• CAS: 494769-85-6
• 化学式: C₂₃H₃₃N₃O
• 分子量: 367.535
• InChiKey: KFDITCODWPDSEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-phenyl-1,4,8-triazaspiro[4.5]decan-2-one 、 1-萘烷酮 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 8-decahydronaphthalen-2-yl-4-phenyl-1,4,8-triazaspiro[4.5]decan-2-one
  参考文献：
  名称：

  4-OXOIMIDAZOLIDINE-2-SPIROPIPERIDINE DERIVATIVE

  摘要：

  公开号：

  EP1420020B1

文献信息

• 4-oxoimidazolidine-2-spiropiperidine derivatives
  申请人：Hashimoto Masaya

  公开号：US20050004363A1

  公开（公告）日：2005-01-06

  The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A 1 , A 2 , A 3 , A 4 and A 5 stand for optionally halogen-substituted methine, or nitrogen atom; R 1 and R 2 stand for lower alkyl or the like; R 3 stands for hydrogen or lower alkyl; R 4 and R 5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like] or salts thereof. These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

  本发明涉及一种由通式[I]所表示的4-氧代咪唑啉-2-螺环哌啶衍生物[其中A1、A2、A3、A4和A5代表可选的卤代亚甲基或氮原子；R1和R2代表低碳基或类似物；R3代表氢或低碳基；R4和R5代表氢或可选地用羟基等替代的低碳基]或其盐。这些化合物作为伤害感受受体激动剂，可用作镇痛剂、缓解对麻醉镇痛剂的耐受性、缓解对麻醉镇痛剂的依赖、镇痛增强剂、抗肥胖剂、改善大脑功能的药物、治疗精神分裂症的药物、治疗退行性神经疾病的药物、抗焦虑剂或抗抑郁剂以及治疗尿崩症和多尿症的药物等。
• 4-Oxoimidazolidine-2-spiropiperidine derivatives
  申请人：Hashimoto Masaya

  公开号：US20070078153A1

  公开（公告）日：2007-04-05

  The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A 1 , A 2 , A 3 , A 4 and A 5 stand for optionally halogen-substituted methine, or nitrogen atom; R 1 and R 2 stand for lower alkyl or the like; R 3 stands for hydrogen or lower alkyl; R 4 and R 5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like]or salts thereof These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

  本发明涉及一种由通式[I]表示的4-氧代咪唑啉-2-螺环吡啶衍生物[其中A1、A2、A3、A4和A5代表可选的卤代亚甲基或氮原子；R1和R2代表较低的烷基或类似物；R3代表氢或较低的烷基；R4和R5代表氢或较低的烷基，该烷基可选地被羟基等取代]或其盐。这些化合物作为伤害感受器激动剂，可用作镇痛剂、缓解对麻醉镇痛剂的耐受性、缓解对麻醉镇痛剂的依赖、镇痛增强剂、抗肥胖剂、改善脑功能的药物、治疗精神分裂症的药物、治疗退行性神经病的药物、抗焦虑剂或抗抑郁剂和治疗尿崩症和多尿症的药物等。
• US7192964B2
  申请人：——

  公开号：US7192964B2

  公开（公告）日：2007-03-20
• US7557117B2
  申请人：——

  公开号：US7557117B2

  公开（公告）日：2009-07-07
• 4-OXOIMIDAZOLIDINE-2-SPIROPIPERIDINE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1420020B1

  公开（公告）日：2008-05-28