(4S,4aS,7S,7aR,12bS)-4a,7,9-trihydroxy-3-methyl-2,4,7,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-13-one;hydrochloride

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4S,4aS,7S,7aR,12bS)-4a,7,9-trihydroxy-3-methyl-2,4,7,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-13-one;hydrochloride
• 化学式: C17H18ClNO5
• 分子量: 351.8
• InChiKey: MQKOJVILJQRWMH-AKXNDGCSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] PROCESS FOR OBTAINING 3,14-DIACETYLOXYMORPHONE FROM ORIPAVINE<br/>[FR] PROCÉDÉ D'OBTENTION DE 3,14-DIACÉTYLOXYMORPHONE À PARTIR D'ORIPAVINE
  申请人：ALCALIBER INVESTIGACIÓN DESARROLLO E INNOVACIÓN S L

  公开号：WO2017207519A1

  公开（公告）日：2017-12-07

  The present invention relates to a new process for obtaining 3,14-diacetyloxymorphone from oripavine, a process to transform the obtained 3,14-diacetyloxymorphone into a noroxymorphone and a process to transform said noroxymorphone into naloxone, naltrexone, nalbuphine, nalfurafine or nalmefene.

  本发明涉及一种从欧洲罂粟碱中获得3,14-二乙酰氧吗啡酮的新工艺，将获得的3,14-二乙酰氧吗啡酮转化为诺罂吗啡的过程，以及将所述诺罂吗啡转化为纳洛酮、纳曲酮、纳布啡、纳福啡或纳美非那的工艺。
• [EN] PROCESS FOR IMPROVED OPIOID SYNTHESIS<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE AMÉLIORÉE D'OPIOÏDES
  申请人：RHODES TECHNOLOGIES

  公开号：WO2014013313A1

  公开（公告）日：2014-01-23

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  用作制备阿片类药物的起始物质或中间物质的化合物和组合物，例如氧吗啡基和/或氧吗啡盐; 制备这些化合物和组合物的过程; 在制备API和制药剂量形式中使用这些化合物和组合物的用途; 以及在治疗医疗状况中使用所述API和制药剂量形式的用途。
• PROCESS FOR IMPROVED OPIOID SYNTHESIS
  申请人：RHODES TECHNOLOGIES

  公开号：US20150315203A1

  公开（公告）日：2015-11-05

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  化合物和组合物可用作制备阿片类药物的起始物质或中间物质，例如氧吗啡基和/或氧吗啡盐；制备这些化合物和组合物的过程；这些化合物和组合物在制备API和制药剂量形式中的用途；以及所述API和制药剂量形式在治疗医疗状况中的用途。
• Process for improved opioid synthesis
  申请人：RHODES TECHNOLOGIES

  公开号：US10316042B2

  公开（公告）日：2019-06-11

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  用作制备阿片类药物的起始原料或中间原料的化合物和组合物，包括氧吗啡酮碱和/或氧吗啡酮盐；制备这些化合物和组合物的工艺；这些化合物和组合物在制备原料药和药物剂型中的用途；以及上述原料药和药物剂型在治疗疾病中的用途。
• PROCESS FOR OBTAINING 3,14-DIACETYLOXYMORPHONE FROM ORIPAVINE
  申请人：Alcaliber Investigacion Desarrollo e Innovacion SLU

  公开号：EP3252055B1

  公开（公告）日：2018-09-19