N-甲基-6-氧代-1,6-二氢-2-吡啶甲酰胺 | 90151-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N-甲基-6-氧代-1,6-二氢-2-吡啶甲酰胺
• 英文名称: 6-hydroxy-N-methylpicolinamide
• 英文别名: 2-Pyridon-6-carbonsaeure-methylamid；N-methyl-6-oxo-1H-pyridine-2-carboxamide
• CAS: 90151-09-0
• 化学式: C₇H₈N₂O₂
• 分子量: 152.153
• InChiKey: ZZWSXEDSNLRKAC-UHFFFAOYSA-N

物化性质

• 沸点：
  496.5±45.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-甲基-6-氧代-1,6-二氢-2-吡啶甲酰胺 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 [6-(Methylcarbamoyl)pyridin-2-yl] methanesulfonate
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates

  摘要：

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.

  DOI：

  10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e
• 作为产物：
  描述：

  6-羟基吡啶-2-羧酸 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 N-甲基-6-氧代-1,6-二氢-2-吡啶甲酰胺
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates

  摘要：

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.

  DOI：

  10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e

文献信息

• CYCLOPROPYLAMINES AS LSD1 INHIBITORS
  申请人：INCYTE CORPORATION

  公开号：US20150225401A1

  公开（公告）日：2015-08-13

  The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

  本发明涉及环丙胺衍生物，其为LSD1抑制剂，可用于治疗癌症等疾病。
• Cyclopropylamines as LSD1 inhibitors
  申请人：Incyte Corporation

  公开号：US10174030B2

  公开（公告）日：2019-01-08

  The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

  本发明涉及环丙胺衍生物，它们是治疗癌症等疾病的 LSD1 抑制剂。
• CYCLOPROPYLAMINES FOR USE AS LSD1 INHIBITORS
  申请人：Incyte Corporation

  公开号：EP3626713B1

  公开（公告）日：2021-09-29
• US9670210B2
  申请人：——

  公开号：US9670210B2

  公开（公告）日：2017-06-06
• [EN] CYCLOPROPYLAMINES AS LSD1 INHIBITORS<br/>[FR] CYCLOPROPYLAMINES EN TANT QU'INHIBITEURS DE LSD1
  申请人：INCYTE CORP

  公开号：WO2015123465A1

  公开（公告）日：2015-08-20

  The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.