1-cyclopentyl-4,4-bis(methoxycarbonyl)-1,4-dihydropyridine | 839721-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-cyclopentyl-4,4-bis(methoxycarbonyl)-1,4-dihydropyridine
• 英文别名: Dimethyl 1-cyclopentylpyridine-4,4-dicarboxylate
• CAS: 839721-81-2
• 化学式: C₁₄H₁₉NO₄
• 分子量: 265.309
• InChiKey: QIVBYVPJUCUPLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-cyclopentyl-4,4-bis(methoxycarbonyl)-1,4-dihydropyridine 在 吡啶 、 溴 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以91%的产率得到Dimethyl 3,5-dibromo-1-cyclopentylpyridine-4,4-dicarboxylate
  参考文献：
  名称：

  An investigation of the bromination of 1,4-dihydropyridine rings

  摘要：

  Conditions for bromination at the C3 and C5 positions of a 1,4-dihydropyridine (DHP) were investigated. The effect of base concentration, base type, reaction temperature, and solvent were examined. DHP derivatives with ester and amide moieties were synthesized and brominated. The bromine atoms can be replaced by other substituents, utilizing Suzuki cross coupling. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.146
• 作为产物：
  描述：

  dimethyl 2,2-bis((1,3-dioxolan-2-yl)methyl)malonate 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 1-cyclopentyl-4,4-bis(methoxycarbonyl)-1,4-dihydropyridine
  参考文献：
  名称：

  Concise synthetic strategy toward cyclic α,α-disubstituted α-amino acids bearing a δ-nitrogen atom: chiral 1-substituted 4-aminopiperidine-4-carboxylic acids

  摘要：

  A concise synthetic strategy toward cyclic alpha,alpha-disubstituted alpha-amino acids, 1-substituted 4-aminopiperidine-4-carboxylic acids have been developed. The synthetic route is a reductive amination of dimethyl bis(dioxoianemethyl)malonate with various amines, followed by Curtius rearrangement. This synthetic route is capable of synthesizing 4-aminopiperidine-4-carboxylic acids bearing a bulky substituent and optically active ones bearing a pendent chiral substituent, by the change of condensed amines. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.11.004

文献信息

• CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST CONTAINING CATALYST COMPONENT AND USE THEREOF
  申请人：Beijing Lihe Technology Ltd.

  公开号：US20170088642A1

  公开（公告）日：2017-03-30

  A catalyst component for olefin polymerization, comprising Mg, Ti, a halogen and an electron donor, wherein the electron donor is at least one unsaturated ring-substituted diacid ester compound. Also provided is a catalyst containing the catalyst component and the use of the catalyst in an olefin polymerization, e.g., propylene polymerization.

  一种用于烯烃聚合的催化剂组分，包括Mg、Ti、卤素和电子给体，其中电子给体至少为一种不饱和环取代二酸酯化合物。还提供了含有该催化剂组分的催化剂以及在烯烃聚合中使用该催化剂，例如丙烯聚合。
• OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF
  申请人：Renqiu Lihe Technology Ltd.

  公开号：US20170355792A1

  公开（公告）日：2017-12-14

  Provided is an olefin polymerization catalyst carrier with a general structure formula of Mg(OR I ) n (OR II ) 2-n , wherein: 0≦n≦2, and R I and R II can be the same or different and are each independently selected from a C 1 -C 20 hydrocarbon group. In the X-ray diffraction pattern of the catalyst carrier, there are a set of diffraction peaks in the range of a 2θ diffraction angle of 5°-15°, and the set of diffraction peaks contain 1-4 main diffraction peaks. Also disclosed is an olefin polymerization solid catalyst component which is prepared from the carrier Mg(OR I ) n (OR II ) 2-n , a titanium compound, and at least one electron donor compound. In addition, also disclosed is an olefin polymerization catalyst containing the solid catalyst component, at least one organic aluminum compound, and optionally, an external electron donor compound.
• Concise synthetic strategy toward cyclic α,α-disubstituted α-amino acids bearing a δ-nitrogen atom: chiral 1-substituted 4-aminopiperidine-4-carboxylic acids
  作者：Makoto Oba、Masakazu Tanaka、Yukiko Takano、Hiroshi Suemune

  DOI：10.1016/j.tet.2004.11.004

  日期：2005.1

  A concise synthetic strategy toward cyclic alpha,alpha-disubstituted alpha-amino acids, 1-substituted 4-aminopiperidine-4-carboxylic acids have been developed. The synthetic route is a reductive amination of dimethyl bis(dioxoianemethyl)malonate with various amines, followed by Curtius rearrangement. This synthetic route is capable of synthesizing 4-aminopiperidine-4-carboxylic acids bearing a bulky substituent and optically active ones bearing a pendent chiral substituent, by the change of condensed amines. (C) 2004 Elsevier Ltd. All rights reserved.
• An investigation of the bromination of 1,4-dihydropyridine rings
  作者：Ori Rorlik、Zeev Tashma、Claudia M. Barzilay、Morris Srebnik

  DOI：10.1016/j.tetlet.2010.11.146

  日期：2011.2

  Conditions for bromination at the C3 and C5 positions of a 1,4-dihydropyridine (DHP) were investigated. The effect of base concentration, base type, reaction temperature, and solvent were examined. DHP derivatives with ester and amide moieties were synthesized and brominated. The bromine atoms can be replaced by other substituents, utilizing Suzuki cross coupling. (C) 2010 Elsevier Ltd. All rights reserved.