2-(2-Methylprop-1-enyl)benzenethiol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 2-(2-Methylprop-1-enyl)benzenethiol
• 英文别名: 2-(2-methylprop-1-enyl)benzenethiol
• 化学式: C₁₀H₁₂S
• 分子量: 164.27
• InChiKey: BFLKTUOAMVSLGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• A Fluorescent Chemical Sensor for Biological Amines
  申请人：THE CURATORS OF THE UNIVERSITY OF MISSOURI

  公开号：US20160274091A1

  公开（公告）日：2016-09-22

  The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds. Especially, for the selective labeling and imaging of catecholamines in live and fixed secretory cells.

  该发明提供了一种多种荧光感应化合物，通常表征为具有香豆素-3-醛骨架的化合物，其中在骨架的C4位置具有一个芳基基团。进一步提供了一种使用这些化合物在生物样本中检测初级胺的方法。特别适用于对活体和固定分泌细胞中儿茶酚胺进行选择性标记和成像。
• AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY
  申请人：Compound Handling B.V.

  公开号：US20150073019A1

  公开（公告）日：2015-03-12

  A compound having the structure according to formula III wherein: X is NH or S; R 1 is H or (1C-4C)alkyl; R 2 is (1C-4C)alkyl, phenyl or a monocyclic aromatic ring having one or more N-, O- or S-atoms in the ring, which alkyl, phenyl or aromatic ring is optionally substituted with one or more groups selected from (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, phenyloxy, phenylthio, halogen, or nitro; R 3 and R 4 are each independently H, (1C-6C)alkyl, (2C-6C) alkenyl, (2C-6C)alkynyl, cyano, (3C-6C)cycloalkyl, phenyl, a monocyclic aromatic ring having one or more N-, O- or S-atoms in the ring, a monocyclic non-aromatic ring having one or more N-, O- or S-atoms in the ring, each optionally substituted with hydroxyl, (1C-4C)alkoxy, phenyl, cycloalkyl, piperidyl, piperazinyl, furyl, thienyl, pirazinyl, pyrrolyl, 2H-pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyrrolidonyl, pyrrolinyl, imidazolinyl, imidazolyl, a monocyclic aromatic ring having one or more N-, O- or S-atoms in the ring, whereby each of these optional substituents is optionally further substituted with (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, halogen, nitro or (1C-2C)dioxol forming a ring; or R 3 and R 4 form together pyrrolyl, imidazolyl, pyrazolyl, pyrrolidinyl, pyrrolinylimidazolidinyl, imidazolinyl, piperidyl, piperazinylmorpholinyl, each optionally substituted with (1C-6C)alkyl, phenyl(1C-4C)alkyl, phenylketo(1C-4C)alkyl; R 5 is H, Cl, F, Br, Me, NO 2 , t-butyl, OCF 3 , OCH 3 , CF 3 ; R 6 is H, (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, nitro or halogen; R 7 is H, F, Cl, Br, Me, NO 2 , t-butyl, OCF 3 , OCH 3 , CF 3 ; or pharmaceutically acceptable addition salts thereof for use in treatments of carcinoma, in particular to delay, prevent or reverse metastasis in prostate cancer.

  一种具有III式结构的化合物，其中：X为NH或S；R1为H或(1C-4C)烷基；R2为(1C-4C)烷基、苯基或单环芳香环，在该烷基、苯基或芳香环中，可选地用一种或多种从(1C-4C)烷基、(1C-4C)烷氧基、卤代(1C-4C)烷基、卤代(1C-4C)烷氧基、苯氧基、苯硫基、卤素或硝基中选择的基团进行取代；R3和R4各自独立地为H、(1C-6C)烷基、(2C-6C)烯基、(2C-6C)炔基、氰基、(3C-6C)环烷基、苯基、单环芳香环，在该环中有一个或多个N、O或S原子，单环非芳香环，在该环中有一个或多个N、O或S原子，每个可选地用羟基、(1C-4C)烷氧基、苯基、环烷基、哌啶基、哌嗪基、呋喃基、噻吩基、吡嗪基、异噁唑基、异硫氧噻唑基、吡咯烷酰基、吡咯烷基、咪唑啉基、咪唑基、单环芳香环，在该环中有一个或多个N、O或S原子，其中每个这些可选基团可选地进一步用(1C-4C)烷基、(1C-4C)烷氧基、卤代(1C-4C)烷基、卤代(1C-4C)烷氧基、卤素、硝基或(1C-2C)二氧杂环丙烷取代形成环；或R3和R4共同形成吡咯基、咪唑基、吡嗪基、吡咯烷基、吡咯烷基咪唑啉基、咪唑啉基、哌啶基、哌嗪基、吗啉基，每个可选地用(1C-6C)烷基、苯基(1C-4C)烷基、苯基酮(1C-4C)烷基取代；R5为H、Cl、F、Br、Me、NO2、t-丁基、O 、OCH3、CF3；R6为H、(1C-4C)烷基、(1C-4C)烷氧基、卤代(1C-4C)烷基、卤代(1C-4C)烷氧基、硝基或卤素；R7为H、F、Cl、Br、Me、 、t-丁基、O 、OCH3、 ；或其药学上可接受的盐，用于治疗癌症，特别是延迟、预防或逆转前列腺癌的转移。
• C-TERMINAL HSP90 INHIBITORS TO TREAT PITUITARY ADENOMAS
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：US20150335613A1

  公开（公告）日：2015-11-26

  The present invention relates to C-terminal HSP90 inhibitors, like silibinin, novobiocin and derivatives thereof, stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said compounds and its compositions have been identified as useful for the treatment of pituitary adenomas such as corticotroph adenomas, lactotroph adenomas, somatotroph adenomas and thyrotroph adenomas.

  本发明涉及C-末端HSP90抑制剂，如水飞蓟素、新霉素及其衍生物、立体异构体、前药、溶剂化物、水合物以及这些化合物的药学上可接受的盐，以及包含至少其中一种化合物和药学上可接受的载体、赋形剂和/或稀释剂的制药组合物。所述化合物及其组合物已被确定为治疗垂体腺瘤，如皮质促肾上腺皮质激素瘤、乳腺促性腺激素瘤、生长激素瘤和甲状腺促性腺激素瘤的有用药物。
• A hindered phenol compound, preparation thereof and use thereof as an antioxidant
  申请人：China Petroleum & Chemical Corporation

  公开号：EP2952505A1

  公开（公告）日：2015-12-09

  This invention relates to a novel hindered phenol compound of Formula (I) (wherein the groups R and R' are as defined in the specification), preparation thereof and use thereof as an antioxidant. By using the hindered phenol compound of this invention as an antioxidant, it is possible to produce a lubricant oil composition exhibiting excellent oxidation resistance at elevated temperatures.

  本发明涉及一种新型的式(I)受阻酚化合物（其中基团R和R'如说明书中所定义）、其制备方法及其作为抗氧化剂的用途。通过使用本发明的受阻酚化合物作为抗氧化剂，可以生产出在高温下具有优异抗氧化性的润滑油组合物。
• A HINDERED PHENOL COMPOUND, PREPARATION THEREOF AND USE THEREOF AS AN ANTIOXIDANT
  申请人：China Petroleum & Chemical Corporation

  公开号：EP2952505B1

  公开（公告）日：2018-05-23