N-甲基-N,N-二丙基-1-丙氯化铵 | 75373-66-9

• 物质功能分类: 化学试剂 - 有机试剂 - 胺盐（铵盐）
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-甲基-N,N-二丙基-1-丙氯化铵
• 中文别名: 甲基三丙基氯化铵；三丙基甲基氯化铵；1-十二烷酮,1,1'-[6,7,9,10,12,13,20,21,23,24,26,27-十二氢二苯并[b,n][1,4,7,10,13,16,19,22]八噁环二十四英-2,16(或2,17)-二基]二-(9CI)
• 英文名称: tri-n-propyl-methylammonium chloride
• 英文别名: tripropylmethylammonium chloride；triethylmethylammonium chloride；aliquat-336；methyl-tripropyl-ammonium; chloride；Methyl-tripropyl-ammonium; Chlorid；Methyl tripropyl ammonium chloride；methyl(tripropyl)azanium;chloride
• CAS: 75373-66-9
• 化学式: C₁₀H₂₄N*Cl
• 分子量: 193.76
• InChiKey: ZUCOWQZUGKUQCH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.33
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  sodium thiophenolate 、 N-甲基-N,N-二丙基-1-丙氯化铵 以 丙醇 为溶剂， 反应 7.0h， 以98.1%的产率得到茴香硫醚
  参考文献：
  名称：

  一种合成茴香硫醚的方法

  摘要：

  本发明涉及一种合成茴香硫醚的方法，以苯硫酚钠为反应原料，季铵盐作为甲基化试剂，醇作为溶剂。苯硫酚钠与所述季铵盐的摩尔比为1∶1～1∶5，苯硫酚钠与所述醇溶剂的质量比为1∶1～1∶10，反应温度为50℃～180℃，反应时间为2～24小时。在反应结束后，减压脱除溶剂，用水洗涤反应混合物，收集油相，减压精馏，收集(10mmHg，67‑69℃)馏分。

  公开号：

  CN106432016B
• 作为试剂：
  描述：

  (S)-2-((1S,2R)-2-(tert-butoxycarbonyl)cyclohexyl)butanoic acid 、 溴甲苯 在 N-甲基-N,N-二丙基-1-丙氯化铵 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 16.0h， 以89%的产率得到
  参考文献：
  名称：

  Heterogeneous H-Bonding in a Foldamer Helix

  摘要：

  Structural characterization of new alpha/gamma-peptide foldamers containing the cyclically constrained gamma-amino acid I is described. Crystallographic and 2D NMR analysis shows that gamma residue I promotes the formation of a 12/10-helical secondary structure in alpha/gamma-peptides. This helix contains two different types of internal H-bond, and the data show that the 12-atom C=O(i) -> HN(i+3) H-bond is more favorable than the 10-atom C=O(i) -> HN(i-1) H-bond. Several foldamer helices featuring topologically distinct H-bonds have been discovered, but our findings are the first to show that such H-bonds may differ in their favorability.

  DOI：

  10.1021/jacs.5b03382

文献信息

• [EN] PROCESS FOR THE SYNTHESIS OF DIAMINOPYRIDINE AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE DIAMINOPYRIDINE ET DE COMPOSÉS APPARENTÉS
  申请人：DU PONT

  公开号：WO2009018504A1

  公开（公告）日：2009-02-05

  A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.

  提供一种合成二氨基吡啶的工艺，例如2,6-二氨基吡啶及相关化合物，这些化合物在工业上用作化合物，并作为合成各种有用材料的组分。合成过程通过在铜源存在的情况下以氯氨置换的方式进行。
• [EN] PROCESSES FOR THE SYNTHESIS OF 3-HYDROXYGLUTARONITRILE<br/>[FR] PROCÉDÉS DE SYNTHÈSE DU 3-HYDROXYGLUTARONITRILE
  申请人：DU PONT

  公开号：WO2009026091A1

  公开（公告）日：2009-02-26

  There are disclosed high yield and high productivity processes for preparing 3-hydroxyglutaronitrile by reacting allyl cyanide epoxide with a basic aqueous solution of a cyanide source.

  披露了一种高产量和高生产率的过程，用于通过将烯丙基氰醛环氧与氰源的碱性水溶液反应制备3-羟基戊二腈。
• METHOD FOR PREPARING AN IMPORTANT INTERMEDIATE OF LINAGLIPTIN
  申请人：2Y-CHEM, LTD.

  公开号：US20150274728A1

  公开（公告）日：2015-10-01

  The present invention discloses an improved process for preparing an important intermediate of linagliptin. In particular, disclosed are a process for preparing a compound V which is an important intermediate of linagliptin and has the structure V, and an industrial process of preparing linagliptin having excellent chemical and optical purities, which is an inhibitor of dipeptidyl peptidase-4 (DPP-IV), from the compound V. The process employs a phase-transfer catalyst, is high in yield, easy and simple to handle, environmentally friendly, suitable for industrial mass production, and can be implemented by a “one-pot process”.

  本发明公开了一种改进的制备利那格列汀重要中间体的工艺。具体公开了一种制备化合物V的工艺，该化合物V是利那格列汀的重要中间体，具有结构V，并且从化合物V中制备出具有优异化学和光学纯度的利那格列汀的工业工艺，利那格列汀是二肽基肽酶-4（DPP-IV）的抑制剂。该工艺采用相转移催化剂，产率高，易于操作和简单处理，环保，适合工业大规模生产，并且可以通过“一锅法”实施。
• PROCESS FOR THE SYNTHESIS OF DIAMINOPYRIDINES FROM GLUTARONITRILES
  申请人：Minter Aaron

  公开号：US20100029948A1

  公开（公告）日：2010-02-04

  A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.

  提供了一种液相工艺，用于从戊二腈和相关化合物制造2,6-二氨基吡啶和相关化合物，这些化合物在工业上用作化合物，以及在合成各种有用材料的过程中用作组分。合成过程通过脱氢芳香化过程进行。
• [EN] CONTINUOUS LIQUID-PHASE PROCESS FOR THE SYNTHESIS OF DIAMINOPYRIDINES FROM GLUTARONITRILES<br/>[FR] PROCÉDÉ CONTINU EN PHASE LIQUIDE DE SYNTHÈSE DE DIAMINOPYRIDINES À PARTIR DE GLUTARONITRILES
  申请人：DU PONT

  公开号：WO2010080488A1

  公开（公告）日：2010-07-15

  A liquid-phase, continuous process is provided for the manufacture of 2,6-diaminopyridine and related compounds from glutaronitriles, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.

  提供了一种从戊二腈中制备2,6-二氨基吡啶和相关化合物的液相连续过程，这些化合物在工业上用作化合物，并作为合成各种有用材料的组分。合成通过脱氢芳香化过程进行。