Ethoxyethane;pyrimidin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethoxyethane;pyrimidin-2-amine
• 英文别名: ethoxyethane;pyrimidin-2-amine
• 化学式: C8H15N3O
• 分子量: 169.22
• InChiKey: SZJCPPYAVGEIPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF
  申请人：GE Yu

  公开号：US20140162999A1

  公开（公告）日：2014-06-12

  PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds as represented by Formula I. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection. Also provided are methods for preparing the compounds represented by Formula I.

  本发明涉及一种具有以下式子表示的结构的PIM激酶抑制剂化合物，以及该化合物的异构体、对映体、二对映异构体、互变异构体和药学上可接受的盐。该化合物能够显著抑制PIm激酶活性，并可用于制备用于治疗PIM激酶介导疾病（如癌症、自身免疫疾病、过敏反应或器官移植排斥等）的药物。此外，还提供了制备上述式子所示化合物的方法。
• PYRIMIDINE DERIVATIVES AS CFTR MODULATORS
  申请人：NuBridge BioSciences

  公开号：US20170101395A1

  公开（公告）日：2017-04-13

  A compound having the structure of Formula II, or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof: The compound is useful as CFTR modulator. Further, a method of using the compound and pharmaceutical composition comprising the compound are provided for treating diseases in lungs, pancreas, gastrointestinal system, sinuses, reproductive system, and the sweat glands.

  化合物具有公式II的结构，或其立体异构体，互变异构体或其药学上可接受的盐：该化合物可用作CFTR调节剂。此外，提供了使用该化合物的方法和包含该化合物的药物组合物，用于治疗肺部，胰腺，胃肠系统，鼻窦，生殖系统和汗腺等疾病。
• PYRIMIDINE DERIVATIVES AS PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF
  申请人：Jikai Biosciences, Inc.

  公开号：US20150284373A1

  公开（公告）日：2015-10-08

  PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.

  具有以下化学式（I）结构的PIM激酶抑制剂化合物及其异构体、对映体、互变异构体、互变异构体和药学上可接受的盐。这些化合物能够显著抑制PIm激酶活性，并用于制备用于治疗PIM激酶介导的疾病，如癌症、多药耐药和炎症性肠病的药物。还提供了制备和使用化学式（I）所代表的化合物的方法。
• US9453003B2
  申请人：——

  公开号：US9453003B2

  公开（公告）日：2016-09-27
• US9981945B2
  申请人：——

  公开号：US9981945B2

  公开（公告）日：2018-05-29