2,4,5-triiodobenzoic acid | 35674-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,5-triiodobenzoic acid
• 英文别名: 2,4,5-Trijod-benzoesaeure
• CAS: 35674-21-6
• 化学式: C₇H₃I₃O₂
• 分子量: 499.813
• InChiKey: OKIYNVQMLZHZJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三季戊四醇 、 2,4,5-triiodobenzoic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 [3-(2,4,5-Triiodobenzoyl)oxy-2,2-bis[[3-(2,4,5-triiodobenzoyl)oxy-2,2-bis[(2,4,5-triiodobenzoyl)oxymethyl]propoxy]methyl]propyl] 2,4,5-triiodobenzoate
  参考文献：
  名称：

  FUNCTIONALIZED CALIBRANTS FOR SPECTROMETRY AND CHROMATOGRAPHY

  摘要：

  校准物和制备方法包括使用多功能核心化合物或多功能树状分子的混合物，这些化合物被官能化以产生一系列离子碰撞截面（CCSs）的离散化合物，以校准离子迁移和分子量变化，以校准质荷比（m/z）质谱测量的质量，并用于校准同时测量两个维度的串联仪器。还公开了使用校准物的方法，例如在质谱分析中。

  公开号：

  US20200105513A1
• 作为产物：
  描述：

  2-氨基-4,5-二碘-苯甲酸 在 potassium iodide 作用下， 生成 2,4,5-triiodobenzoic acid
  参考文献：
  名称：

  Wheeler; Johns, American Chemical Journal, 1910, vol. 43, p. 451

  摘要：

  DOI：

文献信息

• Radio-opaque compounds, compositions containing same and methods of their synthesis and use
  申请人：Pathak P. Chandrashekhar

  公开号：US20050036946A1

  公开（公告）日：2005-02-17

  Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable property of the compositions renders them suitable for use in medical field such as drug delivery, imaging. Compounds disclosed in this invention exist as neat liquid. Certain compositions disclosed in this invention form hydrophobic iodine rich domains when dissolved in water, such domains provide better contrasting properties as well as ability to dissolve hydrophobic bioactive drugs. Certain iodinated moieties disclosed in the invention are capable of cross linking natural proteins in situ in presence of suitable catalysts and co-catalysts.

  放射不透明的可生物降解组合物是通过修改合成和天然可生物降解聚合物（如聚乳酸酯）的末端基团与碘化基团形成的。这些组合物的生物降解性使它们适用于医疗领域，如药物输送、成像等用途。本发明中披露的化合物存在于纯净液体中。本发明中披露的某些组合物在水中溶解时形成疏水碘富区域，这些区域提供更好的对比性能以及溶解疏水生物活性药物的能力。本发明中披露的某些碘化基团能够在适当催化剂和共催化剂存在的情况下交联天然蛋白质。
• Radiation-sensitive composition and pattern-formation method using the same
  申请人：Hitachi, Ltd.

  公开号：EP0070198A1

  公开（公告）日：1983-01-19

  A radiation-sensitive composition comprising (i) an iodine-containing azide compound at least a part of which can be fixed substantially in a polymer by exposure to radiation and a polymer, or (ii) an azide compound, and an iodine compound at least a part of which can be fixed substantially in a polymer by exposure to a radiation and a polymer; and a said polymer substantially having compatibility with the azide compound in case (i) or the azide compound and the iodine compound in case (ii). This composition can be subjected to dry development with oxygen plasma after the exposure followed by heating, or it can be developed with an aqueous alkaline solution if the polymer is soluble therein.

  一种对辐射敏感的组合物，包括：(i) 含碘叠氮化合物，其中至少有一部分可通过辐射和聚合物的照射而基本固定在聚合物中，或 (ii) 叠氮化合物和碘化合物，其中至少有一部分可通过辐射和聚合物的照射而基本固定在聚合物中；以及所述聚合物与(i)情况下的叠氮化合物或(ii)情况下的叠氮化合物和碘化合物基本相容。这种组合物可以在曝光后用氧等离子体进行干显影，然后加热；如果聚合物可溶于碱性水溶液，也可以用碱性水溶液显影。
• METHOD FOR INCREASING THE ABILITY OF MAIZE TO UNDERGO ANDROGENESIS, AND PRODUCTS PRODUCED THEREFROM
  申请人：UNITED AGRISEEDS, INC.

  公开号：EP0461178A1

  公开（公告）日：1991-12-18
• RADIO-OPAQUE COMPOUNDS, COMPOSITIONS CONTAINING SAME AND METHODS OF THEIR SYNTHESIS AND USE
  申请人：Pathak Chandrashekhar P.

  公开号：US20100290995A1

  公开（公告）日：2010-11-18

  Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable property of the compositions renders them suitable for use in medical field such as drug delivery, imaging. Compounds disclosed in this invention exist as neat liquid. Certain compositions disclosed in this invention form hydrophobic iodine rich domains when dissolved in water, such domains provide better contrasting properties as well as ability to dissolve hydrophobic bioactive drugs. Certain iodinated moieties disclosed in the invention are capable of cross linking natural proteins in situ in presence of suitable catalysts and co-catalysts.
• IODO-FUNCTIONALIZED POLYMERS AS MASS SPECTROMETRY CALIBRANTS WITH A MASS-DEFECT OFFSET
  申请人：THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  公开号：US20200181327A1

  公开（公告）日：2020-06-11

  The present invention discloses novel calibrants containing between 1 and 5 iodine atoms and methods of making them using linear polymers, hyperbranched polymers, and biological polymers (including but not limited to proteins and peptides.) Methods of using the calibrants are also disclosed, such as mass spectrometry. The novel calibrants disclosed herein have a more cost- and time-efficient synthesis than other calibrants.