(2R)-6-(aminomethyl)-2-methyl-1,2,3,4-tetrahydropyrimidin-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2R)-6-(aminomethyl)-2-methyl-1,2,3,4-tetrahydropyrimidin-4-ol
• 化学式: C₆H₁₃N₃O
• 分子量: 143.19
• InChiKey: PFWMWCJOKQIIPM-NJXYFUOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  70.3
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• TRICYCLIC LACTAM DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20140179732A1

  公开（公告）日：2014-06-26

  Compounds of the formula (I) useful as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors

  化合物的公式（I），用作11-Beta羟基类固醇脱氢酶抑制剂。
• HETEROBIFUNCTIONAL PAN-SELECTIN INHIBITORS
  申请人：GLYCOMIMETICS, INC.

  公开号：US20140178303A1

  公开（公告）日：2014-06-26

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).