(1S,9R,13S)-17-azapentacyclo[7.5.3.210,13.01,10.02,7]nonadeca-2,4,6,11-tetraene

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,9R,13S)-17-azapentacyclo[7.5.3.210,13.01,10.02,7]nonadeca-2,4,6,11-tetraene
• 化学式: C₁₈H₂₁N
• 分子量: 251.4
• InChiKey: RFFFMHDSSYUWRH-DVIIREOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] PROCESS FOR PREPARING 7&bgr;-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7&bgr;-SUBSTITUTED 6α,14α-ETHANOMORPHINANS<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'ÉTHÉNO-6&Agr;,14&Agr;-MORPHINANES À SUBSTITUTION 7&Bgr; ET D'ÉTHANO-6&Agr;,14&Agr;-MORPHINANES À SUBSTITUTION 7&Bgr;
  申请人：RHODES TECHNOLOGIES

  公开号：WO2014102591A1

  公开（公告）日：2014-07-03

  The application is directed to a process for increasing the proportion of 7β-epimer in an 7α/7β-epimer mixture of a 7-substituted 6α,14α-ethenomorphinan or a 7-substituted 6α,14α-ethanomorphinan, and specifically of compounds of Formula (I), wherein G, R2-R4, and are defined as set forth in the specification. The application is also directed to a process for purifying the 7β-epimer from an 7α/7β-epimer mixture of a 7-substituted 6α,14α-ethenomorphinan or a 7-substituted 6α, 14α-ethanomorphinan. The application is also directed to a process for preparing 7β-substituted compounds of Formula Vb wherein G and R2 -R5 are defined as set forth in the specification.

  该申请涉及一种用于增加7-取代6α,14α-乙烯基吗啡或7-取代6α,14α-乙烷基吗啡的7α/7β-异构体混合物中7β-异构体比例的方法，具体地，涉及到公式（I）中G、R2-R4的化合物的方法，其中G、R2-R4的定义如规范中所述。该申请还涉及从7-取代6α,14α-乙烯基吗啡或7-取代6α,14α-乙烷基吗啡的7α/7β-异构体混合物中纯化7β-异构体的方法。该申请还涉及制备公式Vb中G和R2-R5定义如规范中所述的7β-取代化合物的方法。
• PROCESS FOR PREPARING 7 -SUBSTITUTED 6 ,14 -ETHENOMORPHINANS AND 7 -SUBSTITUTED 6 ,14 -ETHANOMORPHINANS
  申请人：Rhodes Technologies

  公开号：EP2941433A1

  公开（公告）日：2015-11-11