6-Tert-butyl-3-methyl-4-propan-2-ylpyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Tert-butyl-3-methyl-4-propan-2-ylpyridazine
• 英文别名: 6-tert-butyl-3-methyl-4-propan-2-ylpyridazine
• 化学式: C₁₂H₂₀N₂
• 分子量: 192.3
• InChiKey: YELNJRYJCFMLDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20140187772A1

  公开（公告）日：2014-07-03

  This invention describes novel pyrazole compounds of formula III: wherein Z 1 , Z 2 , and Z 3 are as described in the specification; Q is —S—, —O—, —N(R 4 )—, or —CH(R 6 )—; R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R 2 and R 2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.