4-amino-N-[(E)-13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylideneamino]-1,2,5-oxadiazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-amino-N-[(E)-13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylideneamino]-1,2,5-oxadiazole-3-carboxamide
• 化学式: C₁₄H₇N₉O₃
• 分子量: 349.26
• InChiKey: KLSWJENGNAPRTN-QGMBQPNBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  171
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Survivin-targeting anti-tumor agents and uses thereof
  申请人：Indiana University Research and Technology Corporation

  公开号：US10517871B2

  公开（公告）日：2019-12-31

  Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure.

  本研究公开了通过施用一种或多种靶向二聚体蛋白存活素的化合物来治疗各种癌症的方法。还公开了含有此类化合物的药物组合物，以及鉴定靶向致癌二聚体蛋白的抗癌化合物的一般方法。可用于所公开的治疗方法和药物组合物的示例化合物具有如下化学结构。
• SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF
  申请人：Indiana University Research and Technology Corporation

  公开号：US20200222398A1

  公开（公告）日：2020-07-16

  Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure:
• [EN] SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF<br/>[FR] AGENTS ANTI-TUMEUR CIBLANT LA SURVIVINE ET LEUR UTILISATION
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2016187046A1

  公开（公告）日：2016-11-24

  Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure.