(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-N-(phosphanylidynemethyl)-6-(trifluoromethyl)-1,3-oxazinan-2-imine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-N-(phosphanylidynemethyl)-6-(trifluoromethyl)-1,3-oxazinan-2-imine
• 化学式: C₁₇H₁₂F₅N₄OP
• 分子量: 414.27
• InChiKey: BQKSBTQPINNWHP-HOCLYGCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] FLUORO-[1,3]OXAZINES AS BACE1 INHIBITORS<br/>[FR] FLUORO- [1,3] OXAZINES SERVANT D'INHIBITEURS DE LA BACE1
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014114532A1

  公开（公告）日：2014-07-31

  The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

  本发明提供了具有BACE1抑制活性的化合物I的化合物，其制备方法，含有它们的药物组合物以及它们作为治疗活性物质的用途。本发明的活性化合物在治疗和/或预防治疗例如阿尔茨海默病等疾病方面是有用的。
• FLUORO-[1,3]OXAZINES AS BACE1 INHIBITORS
  申请人：WOLTERING Thomas

  公开号：US20150376172A1

  公开（公告）日：2015-12-31

  The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

  本发明提供一种具有BACE1抑制活性的I型化合物，其制造方法，包含它们的制药组合物以及它们作为治疗活性物质的用途。本发明的活性化合物在治疗和/或预防阿尔茨海默病等疾病方面非常有用。