N-[4-[[6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-6-oxohexanoyl]amino]butyl]-7-(diethylamino)-2-oxochromene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-[4-[[6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-6-oxohexanoyl]amino]butyl]-7-(diethylamino)-2-oxochromene-3-carboxamide
• 化学式: C₃₉H₄₂N₄O₅
• 分子量: 646.8
• InChiKey: ODARIZCNIHFLFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  48
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SEALANTS HAVING CONTROLLED DEGRATION
  申请人：PROLYNX LLC

  公开号：US20150352246A1

  公开（公告）日：2015-12-10

  The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.

  本发明提供了密封剂，其中提供了不含有蛋白质反应性基团以结合膜或组织的可生物降解水凝胶，该基团可以通过连接剂选择性引入。连接剂可以是可生物降解的，并且可以通过消除反应进行生物降解。本发明还提供了多层凝胶用于药物传递，其中与要传递药物的组织或器官接触的多孔凝胶被微孔层保护免受周围体液的影响。
• [EN] SEALANTS HAVING CONTROLLED DEGRADATION<br/>[FR] PRODUITS D'ÉTANCHÉITÉ AYANT UNE DÉGRADATION CONTRÔLÉE
  申请人：PROLYNX LLC

  公开号：WO2014116717A1

  公开（公告）日：2014-07-31

  The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.