2-[6-(2-Aminoethyl)-2-[2-[4,6-bis(2-aminoethyl)pyrimidin-5-yl]-4,6-dimethylpyrimidin-5-yl]pyrimidin-4-yl]ethanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[6-(2-Aminoethyl)-2-[2-[4,6-bis(2-aminoethyl)pyrimidin-5-yl]-4,6-dimethylpyrimidin-5-yl]pyrimidin-4-yl]ethanamine
• 英文别名: 2-[6-(2-aminoethyl)-2-[2-[4,6-bis(2-aminoethyl)pyrimidin-5-yl]-4,6-dimethylpyrimidin-5-yl]pyrimidin-4-yl]ethanamine
• 化学式: C₂₂H₃₂N₁₀
• 分子量: 436.6
• InChiKey: QUYGZIGIVPSOEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  181
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES<br/>[FR] COMPOSÉS TRICYCLIQUES BILATÉRALEMENT SUBSTITUÉS POUR LE TRAITEMENT D'UNE INFECTION AU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE DE TYPE 1 (VIH-1) ET AUTRES MALADIES
  申请人：CT DE INVESTIGACIÓN PRÍNCIPE FELIPE

  公开号：WO2014128198A1

  公开（公告）日：2014-08-28

  The invention relates to bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein a-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of a-helical proteins in interaction with other biomolecules.

  该发明涉及双侧取代三环化合物和含有它们的药物组合物，用作药物。由于它们能够与内部RNA环相互作用并模拟蛋白质α-螺旋，这些化合物在治疗和/或预防HIV-1（人类免疫缺陷病毒-1）感染以及其他由其他RNA病毒、革兰氏阳性和革兰氏阴性细菌引起的疾病，或对DNA转录抑制敏感的传染性或慢性疾病，或这些化合物可用于调控RNA内部环功能的传染性或慢性疾病，或这些化合物可用作与其他生物分子相互作用的α-螺旋蛋白的激动剂或抑制剂的传染性或慢性疾病中都具有有效性。
• BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES
  申请人：CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE

  公开号：US20160108024A1

  公开（公告）日：2016-04-21

  The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein α-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of α-helical proteins in interaction with other biomolecules.
• US9586943B2
  申请人：——

  公开号：US9586943B2

  公开（公告）日：2017-03-07