thiamine diphosphate chloride hydrochloride | 23883-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: thiamine diphosphate chloride hydrochloride
• 英文别名: Thiamin-pyrophosphat-hydrochlorid, Hemihydrat；2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate;hydron;dichloride
• CAS: 23883-45-6
• 化学式: C₁₂H₁₉N₄O₇P₂S*ClH*Cl
• 分子量: 497.233
• InChiKey: QTOYIDGNARHVRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.73
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  197
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• COMPOSITION FOR EXTERNAL USE
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：EP1849481A1

  公开（公告）日：2007-10-31

  An object of the present invention is to provide a composition for external use in which the percutaneous absorbability of vitamin A, vitamin A derivative(s), vitamin C, specific vitamin C derivative(s), xanthine derivative(s), ubiquinone(s) and/or hyaluronic acid is improved. The composition for external use is prepared by blending (i) a phospholipid and (ii) a mono- or oligo-glycol ether, together with (iv) at least one bioactive component selected from the group consisting of hyaluronic acid, hyaluronic acid derivatives, vitamin A, vitamin A derivatives, vitamin C, specific vitamin C derivatives, xanthine derivatives, ubiquinones, and salts thereof.

  本发明的目的是提供一种外用组合物，其中维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛素酮和/或透明质酸的经皮吸收性得到改善。 外用组合物的制备方法是将(i)磷脂和(ii)单-或寡-乙二醇醚与(iv)至少一种生物活性成分混合在一起，这些生物活性成分选自透明质酸、透明质酸衍生物、维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛醌及其盐类组成的组。
• COMPOSITION FOR EXTERNAL APPLICATION TO SKIN
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP2269652A1

  公开（公告）日：2011-01-05

  An object of the present invention is to provide an external composition for skin, which can give good warmth without inducing irritation or pain and whose sustainability of warmth is good enough. The external composition for skin of the present invention is characterized in that it contains (A) an agent for giving warmth and (B) at least one selected from the group consisting of fatty acid esters of aliphatic polyhydric alcohols and aromatic carboxylic acid esters of lower alcohols or aliphatic polyhydric alcohols.

  本发明的目的是提供一种皮肤外用组合物，它能在不引起刺激或疼痛的情况下提供良好的保暖效果，而且保暖效果的持续性足够好。本发明的皮肤外用组合物的特征在于，它含有 (A) 一种保暖剂和 (B) 至少一种选自脂肪族多元醇的脂肪酸酯和低级醇或脂肪族多元醇的芳香族羧酸酯。
• COSMETIC COMPOSITION
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP3616683A1

  公开（公告）日：2020-03-04

  Provided is a cosmetic composition that maintains high stability and restrains from becoming cloud. This cosmetic composition is prepared by including (A) polyoxyethylene polyoxypropylene glycol, and (B) an amino acid based surfactant having, in a single molecule thereof, two or more hydrophobic groups and two or more hydrophilic groups. Furthermore, provided is a method of giving a cloudiness-restraining effect to a cosmetic composition, including causing the component (A) and the component (B) to coexist with each other in the cosmetic composition.

  本发明提供了一种化妆品组合物，它能保持高稳定性并防止变浊。 这种化妆品组合物的制备方法是：(A) 聚氧乙烯聚氧丙烯二醇；(B) 氨基酸基表面活性剂，在其单个分子中具有两个或两个以上的疏水基团和两个或两个以上的亲水基团。此外，还提供了一种使化妆品组合物具有抑浊效果的方法，包括使组分（A）和组分（B）在化妆品组合物中共存。
• Borehole fluid with a thiamine-based shale inhibitor
  申请人：Halliburton Energy Services, Inc.

  公开号：US11248156B2

  公开（公告）日：2022-02-15

  A subterranean product extraction composition may include a borehole fluid that may include a thiamine based shale inhibitor active to inhibit reactivity of a formation shale to a base fluid of a borehole fluid. A method of extracting a subterranean product via a borehole may include providing a borehole fluid containing a thiamine-based shale inhibitor and inhibiting reactivity of a formation shale contacted with the borehole fluid. A system for extracting a subterranean product via a borehole may include a tubular having an end in proximity to a formation shale and in fluid communication with a container dispensing a borehole fluid containing a thiamine-based shale inhibitor. The thiamine-based shale inhibitor is inert to the borehole fluid and has superior activity as compared to potassium chloride to inhibit shale reactivity. The borehole fluid may be a drilling fluid. The base fluid may be water.

  一种地下产品提取组合物可包括一种井眼流体，该井眼流体可包括一种硫胺基页岩抑制剂，该硫胺基页岩抑制剂具有抑制地层页岩与井眼流体基液反应的活性。通过井眼提取地下产品的方法可包括提供含有硫胺基页岩抑制剂的井眼流体，并抑制与井眼流体接触的地层页岩的反应性。一种通过井眼提取地下产品的系统可包括一个管状物，其一端靠近地层页岩，并与分配含有硫胺基页岩抑制剂的井眼流体的容器进行流体连通。硫胺基页岩抑制剂对井眼流体是惰性的，与氯化钾相比，硫胺基页岩抑制剂在抑制页岩反应性方面具有更高的活性。井眼流体可以是钻井液。基液可以是水。
• Composition For External Use
  申请人：Harada Ayako

  公开号：US20080207560A1

  公开（公告）日：2008-08-28

  An object of the present invention is to provide a composition for external use in which the percutaneous absorbability of vitamin A, vitamin A derivative(s), vitamin C, specific vitamin C derivative(s), xanthine derivative(s), ubiquinone(s) and/or hyaluronic acid is improved. The composition for external use is prepared by blending (i) a phospholipid and (ii) a mono- or oligo-glycol ether, together with (iv) at least one bioactive component selected from the group consisting of hyaluronic acid, hyaluronic acid derivatives, vitamin A, vitamin A derivatives, vitamin C, specific vitamin C derivatives, xanthine derivatives, ubiquinones, and salts thereof.