N,N-Dimethyl-O-(1,2-distearoyl-sn-glycero-3-phosphoryl)-ethanolamin | 104499-84-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: N,N-Dimethyl-O-(1,2-distearoyl-sn-glycero-3-phosphoryl)-ethanolamin
• 英文别名: DL-α,β-Distearoyl-glycerin-α'phosphorsaeure-<2-dimethylamino-ethylester>；1,2-Distearoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine；[3-[2-(dimethylamino)ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate
• CAS: 104499-84-5
• 化学式: C₄₃H₈₆NO₈P
• 分子量: 776.131
• InChiKey: MPARAOBCZMXIRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.4
• 重原子数：
  53
• 可旋转键数：
  44
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  Hexadecanoic acid 2-[(2-chloro-phenoxy)-(2-dimethylamino-ethoxy)-phosphoryloxy]-1-hexadecanoyloxymethyl-ethyl ester 在 吡啶 、 溶剂黄146 、 亚硝酸异戊酯 作用下， 生成 N,N-Dimethyl-O-(1,2-distearoyl-sn-glycero-3-phosphoryl)-ethanolamin
  参考文献：
  名称：

  Lammers,J.G.; van Boom,J.H., Recueil des Travaux Chimiques des Pays-Bas, 1979, vol. 98, p. 243 - 250

  摘要：

  DOI：

文献信息

• Volkova,L.V. et al., Journal of general chemistry of the USSR, 1965, vol. 35, p. 547 - 550
  作者：Volkova,L.V. et al.

  DOI：——

  日期：——
• CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID MOLECULES THAT MEDIATE RNA INTERFERENCE
  申请人：SIRNA THERAPEUTICS, INC.

  公开号：US20160152973A1

  公开（公告）日：2016-06-02

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity. The present invention is also directed to compounds, compositions, and methods relating to traits, diseases and conditions that respond to the modulation of expression and/or activity of genes involved in gene expression pathways or other cellular processes that mediate the maintenance or development of such traits, diseases and conditions. Specifically, the invention relates to double stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siN A), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against gene expression, including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. The present invention also relates to small nucleic acid molecules, such as siNA, siRNA, and others that can inhibit the function of endogenous RNA molecules, such as endogenous micro-RNA (miRNA) (e.g, miRNA inhibitors) or endogenous short interfering RNA (siRNA), (e.g., siRNA inhibitors) or that can inhibit the function of RISC (e.g., RISC inhibitors), to modulate gene expression by interfering with the regulatory function of such endogenous RNAs or proteins associated with such endogenous RNAs (e.g., RISC), including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. Such small nucleic acid molecules and are useful, for example, in providing compositions to prevent, inhibit, or reduce diseases, traits and conditions that are associated with gene expression or activity in a subject or organism.
• RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION
  申请人：Sirna Therapeutics, Inc.

  公开号：US20160257962A1

  公开（公告）日：2016-09-08

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH1 and mutant IDH1 gene expression and/or activity, and/or modulate an IDH1 or mutant IDH1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules, including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, that are capable of mediating or that mediate RNA interference (RNAi) against IDH1 or mutant IDH1 gene expression.
• US8426581B2
  申请人：——

  公开号：US8426581B2

  公开（公告）日：2013-04-23
• US9322020B2
  申请人：——

  公开号：US9322020B2

  公开（公告）日：2016-04-26