莫沙斯汀 | 3572-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 莫沙斯汀
• 中文别名: 谟克斯汀
• 英文名称: doxylamine
• 英文别名: Chlorfanoxamin；<2-Dimethylamino-aethyl>-<α-methyl-benzhydryl>-aether；1-(1,1-Diphenyl-aethoxy)-2-dimethylamino-aethan；1-Dimethylamino-2-(1,1-diphenyl-aethoxy)-aethan；<2-Dimethylamino-aethyl>-α-methyl-benzhydryl-aether；N,N-Dimethyl-2-(1,1-diphenyl-aethoxy)-aethylamin；[2-(1,1-Diphenyl-aethoxy)-aethyl]-dimethyl-amin；[2-(1,1-diphenyl-ethoxy)-ethyl]-dimethyl-amine；moxastine；2-(1,1-diphenylethoxy)-N,N-dimethylethanamine
• CAS: 3572-74-5
• 化学式: C₁₈H₂₃NO
• 分子量: 269.387
• InChiKey: BBIMHFSPNXQFAH-UHFFFAOYSA-N

物化性质

• 沸点：
  bp0.15 129-136°
• 密度：
  1.0278 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为产物：
  描述：

  1,1-二苯基乙醇 、 二甲氨基氯乙烷盐酸 生成 莫沙斯汀
  参考文献：
  名称：

  Seidlova,V. et al., Collection of Czechoslovak Chemical Communications, 1971, vol. 36, p. 299 - 303

  摘要：

  DOI：

文献信息

• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• (+)-ephedrine as a sympathomimetic drug
  申请人：Warner-Lambert Company LLC

  公开号：EP1310247A1

  公开（公告）日：2003-05-14

  A pharmaceutical composition containing a therapeutically effective amount of (+)-ephedrine and a pharmaceutically aceptable carrier, wherein the composition is substantially free of (-)-ephedrine. The pharmaceutical composition in useful as a decongestant, appetite suppressant, and for treating other conditions often treated with sympathomimetic drugs. The (+)-ephedrine used in the present compositions and methods is substantially free of (-)-ephedrine, and of the adverse side effects associated with administration of (-)-ephedrine.

  一种药物组合物，含有治疗有效量的(+)-麻黄碱和一种药学上可接受的载体，其中该组合物基本上不含(-)-麻黄碱。该药物组合物可用作减充血剂、食欲抑制剂，也可用于治疗经常使用拟交感神经药物治疗的其他病症。本组合物和方法中使用的(+)-麻黄碱基本上不含(-)-麻黄碱，也不会产生与服用(-)-麻黄碱相关的不良副作用。
• Method for formulating large diameter synthetic membrane vesicles
  申请人：Pacira Pharmaceuticals, Inc.

  公开号：EP2813220A2

  公开（公告）日：2014-12-17

  The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

  本发明一般涉及制药科学领域。更具体地说，本发明包括制备含有大直径合成膜囊泡，如多囊脂质体的药物制剂的装置和设备、制备此类制剂的方法，以及使用特定制剂对有需要的受试者进行治疗。此外，还考虑将通过使用本装置和设备生产的含有大直径合成膜囊泡的药物制剂用于对有需要的受试者进行治疗。
• LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES
  申请人：Pacira Pharmaceuticals, Inc.

  公开号：EP3175844A1

  公开（公告）日：2017-06-07

  The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

  本发明一般涉及制药科学领域。更具体地说，本发明包括制备含有大直径合成膜囊泡，如多囊脂质体的药物制剂的装置和设备、制备此类制剂的方法，以及使用特定制剂对有需要的受试者进行治疗。此外，还考虑将通过使用本装置和设备生产的含有大直径合成膜囊泡的药物制剂用于对有需要的受试者进行治疗。