3-[(Z)-docos-13-enoxy]-2-tetradecoxypropan-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 3-[(Z)-docos-13-enoxy]-2-tetradecoxypropan-1-ol
• 化学式: C₃₉H₇₈O₃
• 分子量: 595.0
• InChiKey: WBUGXBXSUANJQS-ZCXUNETKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16
• 重原子数：
  42
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• LIPOHILLIC OLIGONUCLEOTIDE ANALOGS
  申请人：MILTENYI BIOTEC GMBH

  公开号：US20160017325A1

  公开（公告）日：2016-01-21

  Lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula (I), with Oligonucleotide an unmodified or modified nucleic acid of 2-1000 nucleotides in length R=a bond or a linker unit Y═OH, SH or NHR3 X and Z=independently O, S or NR3 R3=hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms R1, R2 branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the provisio that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bond Use of lipophilic oligonucleotide according to Formula I for drug discovery or for transfection of cells.

  含有至少一个脂肪族不饱和碳键的磷酸甘油单元的亲脂性寡核苷酸，其根据式（I）定义，其中，寡核苷酸是长度为2-1000个核苷酸的未修饰或修饰的核酸，R=键或连接单元，Y═OH、SH或NHR3，X和Z=独立的O、S或NR3，R3=氢或带有10至30个碳原子的支链或非支链和/或取代或未取代的烷基、芳基和/或烷基芳基残基，R1、R2=带有10至30个碳原子的支链或非支链和/或取代或未取代的烷基、芳基和/或烷基芳基残基，但至少其中一个残基R1或R2包含至少一个脂肪族碳-碳双键。将式（I）中的亲脂性寡核苷酸用于药物发现或细胞转染。
• Lipophilic oligonucleotide analogs
  申请人：Miltenyi Biotec GmbH

  公开号：EP2781523A1

  公开（公告）日：2014-09-24

  Lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula I with Oligonucleotide = an unmodified or modified nucleic acid of 2 - 1000 nucleotides in length R = a bond or a linker unit Y = OH, SH or NHR3 X and Z = independently O, S or NR3 R3 = hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms R1, R2 = branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the provisio that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bond Use of lipophilic oligonucleotide according to Formula I for drug discovery or for transfection of cells.

  亲脂性寡核苷酸，包含一个磷酸甘油单元，该单元含有至少一个脂肪族不饱和碳键，如式 I 所示 式中 寡核苷酸 = 长度为 2 - 1000 个核苷酸的未修饰或修饰的核酸 R = 键或连接单元 Y = OH、SH 或 NHR3 X 和 Z = 独立的 O、S 或 NR3 R3 = 氢或支链或未支链和/或具有 10 至 30 个碳原子的取代或未取代的烷基、芳基和/或烷基芳基残基 R1、R2 = 具有 10 至 30 个碳原子的支链或未支链和/或取代或未取代的烷基、芳基和/或 烷芳基残基，但 R1 或 R2 残基中至少有一个包含至少一个脂肪族碳-碳双键 将符合式 I 的亲脂寡核苷酸用于药物开发或细胞转染。
• US9803198B2
  申请人：——

  公开号：US9803198B2

  公开（公告）日：2017-10-31
• [EN] LIPOHILLIC OLIGONUCLEOTIDE ANALOGS<br/>[FR] ANALOGUES OLIGONUCLÉOTIDIQUES LIPOPHILES
  申请人：MILTENYI BIOTEC GMBH

  公开号：WO2014147095A1

  公开（公告）日：2014-09-25

  Lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula (I), with Oligonucleotide an unmodified or modified nucleic acid of 2 - 1000 nucleotides in length R = a bond or a linker unit Y = OH, SH or NHR3 X and Z = independently O, S or NR3 R3 = hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms R1. R2 branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the provisio that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bond Use of lipophilic oligonucleotide according to Formula I for drug discovery or for transfection of cells.