N²-(3,4-dichlorobenzyl)-N⁶-methyl-N⁴,N⁸-di-n-propyl-pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraamine hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N²-(3,4-dichlorobenzyl)-N⁶-methyl-N⁴,N⁸-di-n-propyl-pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraamine hydrochloride
• 英文别名: N2-(3,4-dichloro-benzyl)-N6-methyl-N4,N8-di-n-propyl-pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraamine hydrochloride；2-N-[(3,4-dichlorophenyl)methyl]-6-N-methyl-4-N,8-N-dipropylpyrimido[5,4-d]pyrimidine-2,4,6,8-tetramine;hydrochloride
• 化学式: C₂₀H₂₆Cl₂N₈*(x)ClH
• 分子量: 485.8
• InChiKey: AVOSXAJVOOQRJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.45
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  99.7
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N²-(3,4-dichlorobenzyl)-N⁶-methyl-N⁴,N⁸-di-n-propyl-pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraamine 、 hydrochloric acid diethyl ether 、 6-chloro-N²-methyl-N⁴,N⁸-di-n-propylpyrimido[5,4-d]pyrimidine-2,4,8-triamine hydrochloride 在 乙醇 作用下， 以 乙醚 为溶剂， 以to give N2-(3,4-dichloro-benzyl)-N6-methyl-N4,N8-di-n-propyl-pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraamine hydrochloride (51a) (200 mg, 78% y)的产率得到N²-(3,4-dichlorobenzyl)-N⁶-methyl-N⁴,N⁸-di-n-propyl-pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraamine hydrochloride
  参考文献：
  名称：

  NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME

  摘要：

  本发明涉及对呼吸控制疾病或障碍的预防和/或治疗有用的嘧啶并[5,4-d]嘧啶。本发明还包括一种预防和/或治疗受访者的呼吸系统疾病或障碍的方法，包括向受访者施用本发明中至少一种化合物的治疗有效量。本发明还包括一种预防不稳定或稳定受访者呼吸节律的方法，包括向受访者施用本发明中至少一种化合物的治疗有效量。

  公开号：

  US20160046635A1

文献信息

• US9643971B2
  申请人：——

  公开号：US9643971B2

  公开（公告）日：2017-05-09
• [EN] NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DU CONTRÔLE DE LA RESPIRATION ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2014151462A1

  公开（公告）日：2014-09-25

  The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.
• NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US20160046635A1

  公开（公告）日：2016-02-18

  The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.

  本发明涉及对呼吸控制疾病或障碍的预防和/或治疗有用的嘧啶并[5,4-d]嘧啶。本发明还包括一种预防和/或治疗受访者的呼吸系统疾病或障碍的方法，包括向受访者施用本发明中至少一种化合物的治疗有效量。本发明还包括一种预防不稳定或稳定受访者呼吸节律的方法，包括向受访者施用本发明中至少一种化合物的治疗有效量。