4-[(7-Hydroxy-2-oxochromen-4-yl)amino]butanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-[(7-Hydroxy-2-oxochromen-4-yl)amino]butanoic acid
• 英文别名: 4-[(7-hydroxy-2-oxochromen-4-yl)amino]butanoic acid
• 化学式: C₁₃H₁₃NO₅
• 分子量: 263.25
• InChiKey: ZBWVOZRVQRNLNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Synthesis of hydantoin containing peptide products
  申请人：SANOFI-AVENTIS DEUTSCHLAND GMBH

  公开号：US10087221B2

  公开（公告）日：2018-10-02

  The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

  本发明涉及一种合成包含至少一个海因基团的多肽产品的方法。该多肽产品可用作药物多肽质量控制的参考材料，特别是用于外激素多肽的质量控制。此外，本发明还涉及海因砌块、制造这种砌块的方法及其用于合成肽产品的用途。
• SYNTHESIS OF HYDANTOIN CONTAINING PEPTIDE PRODUCTS
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP2976331A1

  公开（公告）日：2016-01-27
• PEPTIDE-BASED NON-PROTEINACEOUS CARGO DELIVERY
  申请人：Feldan Bio Inc.

  公开号：EP3956348A1

  公开（公告）日：2022-02-23
• Synthesis of Hydantoin Containing Peptide Products
  申请人：SANOFI-AVENTIS DEUTSCHLAND GMBH

  公开号：US20160289282A1

  公开（公告）日：2016-10-06

  The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.
• [EN] SYNTHESIS OF HYDANTOIN CONTAINING PEPTIDE PRODUCTS<br/>[FR] SYNTHÈSE DE PRODUITS PEPTIDIQUES CONTENANT DE L'HYDANTOÏNE
  申请人：SANOFI AVENTIS DEUTSCHLAND

  公开号：WO2014147124A1

  公开（公告）日：2014-09-25

  The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.