2-[2-(difluoromethyl)-4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]phenyl]-N-(3H-pyrrol-2-yl)-1H-benzimidazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[2-(difluoromethyl)-4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]phenyl]-N-(3H-pyrrol-2-yl)-1H-benzimidazole-4-carboxamide
• 化学式: C₂₅H₂₄F₂N₄O₄
• 分子量: 482.5
• InChiKey: XCKXUETUTQMRAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  97.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：GLAXOSMITHKLINE LLC

  公开号：US20150057272A1

  公开（公告）日：2015-02-26

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新型的sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于增加细胞寿命，以及治疗和/或预防各种疾病和疾病，包括与衰老或压力相关的疾病或疾病、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块障碍、炎症、癌症和/或潮红症，以及需要增加线粒体活性的疾病或疾病。还提供了包含sirtuin调节化合物与另一种治疗剂的组合物。
• US8846947B2
  申请人：——

  公开号：US8846947B2

  公开（公告）日：2014-09-30