2-ethyl-3-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethyl-3-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide
• 英文别名: 2-ethyl-3-hydroxy-N-[4-(2-oxo-1,3-dihydrobenzo[i][1,4]benzodiazepin-5-yl)phenyl]benzamide
• 化学式: C₂₈H₂₃N₃O₃
• 分子量: 449.509
• InChiKey: BLHRLBVBILGGAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  90.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-ethyl-3-methoxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以52%的产率得到2-ethyl-3-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide
  参考文献：
  名称：

  P2X4 RECEPTOR ANTAGONIST

  摘要：

  公开号：

  EP3020707B1

文献信息

• DRUG FOR TREATING COUGH
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：EP3766497A1

  公开（公告）日：2021-01-20

  The present invention pertains to a medicament for preventing or treating cough, including, as an active ingredient, a compound having P2X4 receptor antagonistic action, a tautomer, stereoisomer, or pharmaceutically acceptable salt of the compound, or a hydrate or solvate thereof.

  本发明涉及一种预防或治疗咳嗽的药物，其活性成分包括具有 P2X4 受体拮抗作用的化合物、该化合物的同分异构体、立体异构体或药学上可接受的盐，或其水合物或溶液。
• P2X4 receptor antagonist
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：US10150744B2

  公开（公告）日：2018-12-11

  The present invention relates to a compound represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R1, R2 and R3 represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(═O), provided that when X is C, Y represents N, and when X is N, Y represents C(═O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).

  本发明涉及由以下通式(I)代表的化合物，该化合物具有P2X4受体拮抗活性(式中，R1、R2和R3代表氢原子、具有1至8个碳原子的烷基、具有1至8个碳原子的烷氧基、卤素原子等，X代表C或N、Y代表N或C(═O)，条件是当X为C时，Y代表N，当X为N时，Y代表C(═O)，实线和折线组成的双线代表单键或双键，n代表0至6的整数，Z代表O、S或原子键，A代表苯环、吡啶环等）。
• MEDICAMENT FOR TREATING COUGH
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：US20210000840A1

  公开（公告）日：2021-01-07

  The present invention pertains to a medicament for preventing or treating cough, including, as an active ingredient, a compound having P2X4 receptor antagonistic action, a tautomer, stereoisomer, or pharmaceutically acceptable salt of the compound, or a hydrate or solvate thereof.
• MEDICAMENT FOR TREATMENT OF MULTIPLE SCLEROSIS
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：US20210121478A1

  公开（公告）日：2021-04-29

  A medicament for preventive and/or therapeutic treatment of multiple sclerosis, especially a pain accompanying multiple sclerosis such as neuropathic pain, which contains a compound having a P2X4 receptor antagonist activity such as a compound represented by the general formula (IH), or a salt thereof, or a hydrate or solvate thereof as an active ingredient.