[(1R,2R,3R,4R)-3-fluoro-2-hydroxy-4-[[5-[1-[(3-iodophenyl)methyl]pyrrole-3-carbonyl]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [(1R,2R,3R,4R)-3-fluoro-2-hydroxy-4-[[5-[1-[(3-iodophenyl)methyl]pyrrole-3-carbonyl]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamate
• 化学式: C₂₂H₂₃FIN₅O₅S
• 分子量: 615.4
• InChiKey: MZXRISJHGBBLPV-OBZYLPMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  158
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：EP3016934B1

  公开（公告）日：2018-01-10
• HETEROARYL INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：US20160355504A1

  公开（公告）日：2016-12-08

  Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra′, Rc, Rf, X2, Rd, Rd′, Re, Re′2, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.
• US9695154B2
  申请人：——

  公开号：US9695154B2

  公开（公告）日：2017-07-04