N-((4-fluorophenyl)(2,4,6-trimethoxyphenyl)methyl)-4-methylbenzenesulfonamide | 1036030-71-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((4-fluorophenyl)(2,4,6-trimethoxyphenyl)methyl)-4-methylbenzenesulfonamide
• 英文别名: N-[(4-fluorophenyl)-(2,4,6-trimethoxyphenyl)methyl]-4-methylbenzenesulfonamide
• CAS: 1036030-71-3
• 化学式: C₂₃H₂₄FNO₅S
• 分子量: 445.512
• InChiKey: QPIJOABSYWDWTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  82.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,3,5-三甲氧基苯 、 N-(4-fluorobenzylidene)-4-methylbenzenesulfonamide 在 三氯化铁 作用下， 以 硝基甲烷 为溶剂， 反应 12.0h， 以52%的产率得到N-((4-fluorophenyl)(2,4,6-trimethoxyphenyl)methyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines

  摘要：

  Iron(III) chloride was discovered highly effective as catalyst in the Friedel-Crafts reactions of electron-rich arenes with imines or aziridines. It was found that reactions of imines were highly substrate-dependent, which generated mono- or double-addition products, while arenes reacted with aziridines regioselectively leading to the formation of desired ring-opening products in 2 min with moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.081

文献信息

• FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines
  作者：Zhiyong Wang、Xiaoyu Sun、Jie Wu

  DOI：10.1016/j.tet.2008.03.081

  日期：2008.5

  Iron(III) chloride was discovered highly effective as catalyst in the Friedel-Crafts reactions of electron-rich arenes with imines or aziridines. It was found that reactions of imines were highly substrate-dependent, which generated mono- or double-addition products, while arenes reacted with aziridines regioselectively leading to the formation of desired ring-opening products in 2 min with moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.