Amphetamine methanesulfonate | 38727-03-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Amphetamine methanesulfonate
• 英文别名: methanesulfonic acid;1-phenylpropan-2-amine
• CAS: 38727-03-6
• 化学式: C10H17NO3S
• 分子量: 231.31
• InChiKey: MXNLPUKSUIQAGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.08
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ABUSE RESISTANT AMPHETAMINE COMPOUNDS<br/>[FR] COMPOSES D'AMPHETAMINE RESISTANT AUX ABUS
  申请人：NEW RIVER PHARMACEUTICALS INC

  公开号：WO2005000334A1

  公开（公告）日：2005-01-06

  The invention describes compounds, compositions and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

  本发明涉及一种将化学基团共价连接到苯丙胺的化合物、组合物和使用方法。这些化合物和组合物可用于减少或预防苯丙胺的滥用和过量使用。这些化合物和组合物在为某些疾病提供抗滥用替代治疗方面具有特殊用途，例如注意力缺陷多动障碍（ADHD）、ADD、嗜睡症和肥胖症。在治疗上，苯丙胺的口服生物利用度保持在治疗上有用的剂量。在更高剂量下，生物利用度显著降低，从而提供了一种减少口服滥用风险的方法。此外，本发明的化合物和组合物通过静脉或鼻腔给药等肌肉注射途径进一步降低苯丙胺的生物利用度，从而进一步限制其滥用风险。
• ABUSE-RESISTANT AMPHETAMINE PRODRUGS
  申请人：Mickle Travis

  公开号：US20100197798A1

  公开（公告）日：2010-08-05

  The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

  本发明描述了一种将化学基团共价连接到苯丙胺的化合物、组合物和使用方法。这些化合物和组合物可用于减少或预防苯丙胺的滥用和过量。这些化合物和组合物在为某些疾病提供抗滥用替代治疗方面具有特殊用途，如注意力缺陷多动障碍（ADHD）、ADD、嗜睡症和肥胖症。在治疗剂量下，苯丙胺的口服生物利用度得以维持。在更高的剂量下，生物利用度大大降低，从而提供了一种减少口服滥用的方法。此外，本发明的化合物和组合物通过肌肉注射或鼻腔给药等静脉或鼻腔途径降低苯丙胺的生物利用度，进一步限制了它们的滥用风险。
• ABUSE RESISTANT AMPHETAMINE COMPOUNDS
  申请人：New River Pharmaceuticals Inc.

  公开号：EP1644019A1

  公开（公告）日：2006-04-12