(+/-)-trans-cinnamylsuccinic acid | 1086223-48-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-trans-cinnamylsuccinic acid
• 英文别名: (+/-)-trans-Cinnamylbernsteinsaeure；2-[(E)-3-phenylprop-2-enyl]butanedioic acid
• CAS: 1086223-48-4
• 化学式: C₁₃H₁₄O₄
• 分子量: 234.252
• InChiKey: USYIGOSTVXJXHA-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  肉桂基琥珀酸 在 sodium carbonate 作用下， 生成 (+/-)-trans-cinnamylsuccinic acid
  参考文献：
  名称：

  Alder; Pascher; Schmitz, Chemische Berichte, 1943, vol. 76, p. 27,48

  摘要：

  DOI：

文献信息

• TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES
  申请人：Forschungszentrum Jülich GmbH/ Abteilung RP-PT

  公开号：EP3659593A1

  公开（公告）日：2020-06-03

  The present invention relates to inhibitors of the enzyme TRMT2A and medical uses thereof. More particularly, the present invention relates to the treatment and the prevention of polyglutamine diseases using TRMT2A inhibitors.

  本发明涉及 TRMT2A 酶的抑制剂及其医疗用途。更具体地说，本发明涉及使用 TRMT2A 抑制剂治疗和预防多聚谷氨酰胺疾病。
• The role of laparoscopy in the management of the impalpable testicle
  作者：D. J. Galvin、H. Bredin

  DOI：10.1007/bf03168955

  日期：2002.4

  Background Laparoscopy can identify patients who would benefit from further surgical intervention. Most importantly it is 100% sensitive in identifying the vanishing testicle.Aims To review the role of laparoscopy in the management of the undescended testis.Methods Thirty-one patients underwent a laparoscopy for an impalpable testicle over a nine-year period at this institution.Results There were 30 successful laparoscopies completed for 31 impalpable testes, 13 of which were normal. All underwent groin exploration of which 11 were located. Seventeen had an abnormal laparoscopy. Of these, 11 were located in the abdomen and four were diagnosed as vanishing testes.Discussion Sixteen per cent of patients had an absent testicle at laparoscopy and were spared any further surgical intervention. In the remaining 84%, over half had their surgical procedure altered as a result of the laparoscopic findings. This experience, has led us to believe that laparoscopy is a safe, reliable and sensitive procedure crucial to the management of the impalpable testis.
• [EN] TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES<br/>[FR] INHIBITEURS DE TRMT2A UTILISÉS POUR LE TRAITEMENT DE MALADIES À POLYGLUTAMINE
  申请人：FORSCHUNGSZENTRUM JUELICH GMBH FACHBEREICH PATENTE R P

  公开号：WO2020109233A2

  公开（公告）日：2020-06-04

  The present invention relates to inhibitors of the enzyme TRMT2A and medical uses thereof. More particularly, the present invention relates to the treatment and the prevention of polyglutamine diseases using TRMT2A inhibitors.
• Alder; Pascher; Schmitz, Chemische Berichte, 1943, vol. 76, p. 27,48
  作者：Alder、Pascher、Schmitz

  DOI：——

  日期：——