1-(4-Ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)thio]-2-propen-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(4-Ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)thio]-2-propen-1-one
• 英文别名: (E)-1-(4-ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)sulfanyl]prop-2-en-1-one
• 化学式: C₁₉H₁₈N₂OS
• 分子量: 322.4
• InChiKey: OEFOUCPCKSVCJM-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHODS AND COMPOSITIONS FOR TREATMENT OF MYELODYSPLASTIC SYNDROMES AND/OR ACUTE MYELOID LEUKEMIAS
  申请人：Children's Hospital Medical Center

  公开号：US20210299102A1

  公开（公告）日：2021-09-30

  Disclosed are methods for treating a myelodyspastic syndrome (MDS) and/or an acute myeloid leukemia (AML) in an individual in need thereof. Further disclosed are compositions for use in the disclosed methods, used for treating a myelodyspastic syndrome (MDS) and/or an acute myeloid leukemia (AML) in an individual in need thereof.
• [EN] METHODS AND COMPOSITIONS FOR TREATMENT OF MYELODYSPASTIC SYNDROMES AND/OR ACUTE MYLEOID LEUKEMIAS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DE SYNDROMES MYÉLODYSPASTIQUES ET/OU DE LEUCÉMIES AIGUËS MYLÉOÏDES
  申请人：CHILDRENS HOSPITAL MED CT

  公开号：WO2018081361A1

  公开（公告）日：2018-05-03

  Disclosed are methods for treating a myelodyspastic syndrome (MDS) and/or an acute myeloid leukemia (AML) in an individual in need thereof. Further disclosed are compositions for use in the disclosed methods, used for treating a myelodyspastic syndrome (MDS) and/or an acute myeloid leukemia (AML) in an individual in need thereof.