2-cycloheptyladamantane | 132103-44-7

• 分子结构分类: 有机化合物 - 碳氢化合物 - 多环烃
• 英文名称: 2-cycloheptyladamantane
• CAS: 132103-44-7
• 化学式: C₁₇H₂₈
• 分子量: 232.409
• InChiKey: GAOKCJVVNNIEIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  7-(2-Adamantylidene)-1,3,5-cycloheptatriene 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 21.0h， 以99%的产率得到2-cycloheptyladamantane
  参考文献：
  名称：

  Stereomutation of 7-tropylionorbornane, 2-tropyliobicyclo[2.2.2]octane, and 2-tropylioadamantane: evidence for the intermediacy of heptafulvenes

  摘要：

  The perchlorates of 7-tropylionorbornane (3), 2-tropyliobicyclo[2.2.2]octane (4), and 2-tropylioadamantane (5) were found to undergo stereomutation in acetonitrile at 25-85-degrees-C, as evidenced by following the change in the C-13 NMR spectra of their deuterium-labeled compounds in acetonitrile-d3. Addition of tetracyanoethylene to their solutions in acetonitrile gave the [8 + 2] cycloaddition products of the corresponding heptafulvenes, indicating the intermediacy of the heptafulvenes. This stereomutation was too slow to detect in dichloromethane at the same temperature. Therefore, it is concluded that the stereomutation proceeds through the abstraction of the alpha-hydrogen by acetonitrile as a base followed by the protonation of the heptafulvene intermediate from the rear side. The entropies of activation which are significantly negative and large indicate abstraction of the alpha-hydrogen is the rate-determining step. The enthalpy of activation for the norbornane system (22.1 +/- 1.1 kcal/mol) is about 8 kcal/mol greater than that for the bicyclo[2.2.2]octane system (15.4 +/- 1.1 kcal/mol) and that for the adamantane system (13.1 +/- 1.3 kcal/mol). Molecular mechanics calculations (MMPI, MM2') for the three heptafulvenes and the corresponding phenyl derivatives (instead of the tropylium ions) indicated that the angle strain at the 8-position of the heptafulvenes controls the rate of the steremutation.

  DOI：

  10.1021/jo00003a028

文献信息

• IKAI, KEIZO;TAKEUCHI, KENICHI;KINOSHITA, TOMOMI;HAGA, KENICHI;KOMATSU, KO+, J. ORG. CHEM., 56,(1991) N, C. 1052-1058
  作者：IKAI, KEIZO、TAKEUCHI, KENICHI、KINOSHITA, TOMOMI、HAGA, KENICHI、KOMATSU, KO+

  DOI：——

  日期：——